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Ann Rheum Dis. Oct 1981; 40(5): 501–502.
PMCID: PMC1000789

Serum histidine in rheumatoid arthritis: a family study


We have compared free serum histidine in patients with rheumatoid arthritis, their blood relatives, and their non-blood relatives. The hypohistidinaemia of rheumatoid arthritis is acquired with the disease and does not provide a biochemical marker of those at risk.

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Selected References

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  • Gerber DA. Low free serum histidine concentration in rheumatoid arthritis. A measure of disease activity. J Clin Invest. 1975 Jun;55(6):1164–1173. [PMC free article] [PubMed]
  • Panayi GS, Wooley P, Batchelor JR. Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs. Br Med J. 1978 Nov 11;2(6148):1326–1328. [PMC free article] [PubMed]
  • Armstrong MD, Stave U. A study of plasma free amino acid levels. VII. Parent-child and sibling correlations in amino acid levels. Metabolism. 1973 Oct;22(10):1263–1268. [PubMed]
  • Gerber DA, Gerber MG. Specificity of a low free serum histidine concentration for rheumatoid arthritis. J Chronic Dis. 1977 Feb;30(2):115–127. [PubMed]
  • Gerber DA. Determination of histidine in serum with o-phthaldialdehyde. Anal Biochem. 1970 Apr;34(2):500–504. [PubMed]

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