• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of annrheumdAnnals of the Rheumatic DiseasesView this articleSubmit a manuscriptReceive email alertsContact usBMJ
Ann Rheum Dis. Apr 1980; 39(2): 147–151.
PMCID: PMC1000499

Immunocytological studies of lymph nodes in rheumatoid arthritis and malignant lymphoma.

Abstract

Lymph nodes obtained from 9 patients with active rheumatoid arthritis were stained by immunological techniques permitting identification of B and T cell areas within the nodes. The lymph nodes were also compared with those obtained from patients with lymphoma. The rheumatoid lymph nodes showed prominent B cell staining in the follicular centres by the EAC and fluoresceinated immunoglobulin techniques. Interfollicular areas were intensely stained with anti-theta globulin. In contrast, lymphoma nodes stained less intensely with fluoresceinated immunoglobulins but stained like benign nodes with EAC. The difference in staining may reflect the degree of disorganisation of the neoplastic follicle and/or the different sensitivity of these 2 methods in the detection of B cells. The differences in staining are helpful in distinguishing the benign changes associated with chronic inflammation from neoplastic B cell proliferative changes seen in lymph nodes.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.3M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • MOTULSKY AG, WEINBERG S, SAPHIR O, ROSENBERG E. Lymph nodes in rheumatoid arthritis. AMA Arch Intern Med. 1952 Nov;90(5):660–676. [PubMed]
  • CRUICKSHANK B. Lesions of lymph nodes in rheumatoid disease and in disseminated lupus erythematosus. Scott Med J. 1958 Mar;3(3):110–119. [PubMed]
  • Robertson MD, Hart FD, White WF, Nuki G, Boardman PL. Rheumatoid lymphadenopathy. Ann Rheum Dis. 1968 May;27(3):253–260. [PMC free article] [PubMed]
  • Muirden KD. Lymph node iron in rheumatoid arthritis. Histology, ultrastructure, and chemical concentration. Ann Rheum Dis. 1970 Jan;29(1):81–88. [PMC free article] [PubMed]
  • Jaffe ES, Shevach EM, Frank MM, Berard CW, Green I. Nodular lymphoma--evidence for origin from follicular B lymphocytes. N Engl J Med. 1974 Apr 11;290(15):813–819. [PubMed]
  • Shevach EM, Jaffe ES, Green I. Receptors for complement and immunoglobulin on human and animal lymphoid cells. Transplant Rev. 1973;16:3–28. [PubMed]
  • ROPES MW, BENNETT GA, COBB S, JACOX R, JESSAR RA. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed]
  • Tannenbaum H, Pinkus GS, Anderson LG, Schur PH. Immunologic characterization of the mononuclear cell infiltrates in rheumatoid synovia, in rheumatoid nodules, and in lip biopsies from patients with Sjögren's syndrome. Arthritis Rheum. 1975 Jul-Aug;18(4):305–314. [PubMed]
  • Van Boxel JA, Paget SA. Predominantly T-cell infiltrate in rheumatoid synovial membranes. N Engl J Med. 1975 Sep 11;293(11):517–520. [PubMed]
  • Husby G, Strickland RG, Caldwell JL, Williams RC., Jr Localization of T and B cells and alpha fetoprotein in hepatic biopsies from patients with liver disease. J Clin Invest. 1975 Nov;56(5):1198–1209. [PMC free article] [PubMed]
  • Bankhurst AD, Husby G, Williams RC., Jr Predominance of T cells in the lymphocytic infiltrates of synovial tissues in rheumatoid arthritis. Arthritis Rheum. 1976 May-Jun;19(3):555–562. [PubMed]
  • Gajl-Peczalska KJ, Park BH, Biggar WD, Good RA. B and T lymphocytes in primary immunodeficiency disease in man. J Clin Invest. 1973 Apr;52(4):919–928. [PMC free article] [PubMed]
  • Braylan RC, Rappaport H. Tissue immunoglobulins in nodular lymphomas as compared with reactive follicular hyperplasias. Blood. 1973 Oct;42(4):579–589. [PubMed]
  • Winchester RJ, Fu SM, Hoffman T, Kunkel HG. IgG on lymphocyte surfaces; technical problems and the significance of a third cell population. J Immunol. 1975 Apr;114(4):1210–1212. [PubMed]
  • Kurnick JT, Grey HM. Relationship between immunoglobulin-bearing lymphocytes and cells reactive with sensitized human erythrocytes. J Immunol. 1975 Jul;115(1):305–307. [PubMed]
  • Aisenberg AC, Long JC. Lymphocyte surface characteristics in malignant lymphoma. Am J Med. 1975 Mar;58(3):300–306. [PubMed]
  • Lukes RJ, Collins RD. Immunologic characterization of human malignant lymphomas. Cancer. 1974 Oct;34(4 Suppl):suppl–suppl:1503. [PubMed]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...