Logo of annrheumdAnnals of the Rheumatic DiseasesVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Ann Rheum Dis. 1979 Feb; 38(1): 36–39.
PMCID: PMC1000315

A thermographic and clinical comparison of three intra-articular steroid preparations in rheumatoid arthritis.


We have compared three intra-articular steroid preparations in a double blind study on 30 patients with rheumatoid arthritis and bilateral synovitis of the knees. One knee was injected with 1.0 ml of either prednisolone t-butyl acetate, methyl prednisolone acetate, or triamcinolone hexacetonide, and the patients were followed up for 6 weeks with regular clinical and thermographic assessments. Thermographic improvement was seen with all 3 drugs but was greatest initially and longest lasting with triamcinolone. No significant systemic improvement was seen with any drug after a single injection, though all 3 steroid preparations suppressed endogenous cortisol.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (578K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bain LS, Balch HW, Jacomb RG. Parenteral administration of 6-alpha-methylprednisolone-21- acetate. I. Intra-articular injection: comparison with hydrocortisone acetate. Ann Phys Med. 1967 May;9(2):43–48. [PubMed]
  • Bird HA, Ring EF, Daniel R, Bacon PA. Comparison of intra-articular methotrexate with intra-articular triamcinolone hexacetonide by thermography. Curr Med Res Opin. 1977;5(2):141–146. [PubMed]
  • Collins AJ, Ring EF, Cosh JA, Bacon PA. Quantitation of thermography in arthritis using multi-isothermal analysis. I. The thermographic index. Ann Rheum Dis. 1974 Mar;33(2):113–115. [PMC free article] [PubMed]
  • Esselinckx W, Bacon PA, Ring EF, Crooke D, Collins AJ, Demottaz D. A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis. Br J Clin Pharmacol. 1978 May;5(5):447–451. [PMC free article] [PubMed]
  • HOLLANDER JL, BROWN EM, Jr, JESSAR RA, BROWN CY. Hydrocortisone and cortisone injected into arthritic joints; comparative effects of and use of hydrocortisone as a local antiarthritic agent. J Am Med Assoc. 1951 Dec 22;147(17):1629–1635. [PubMed]
  • MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. [PMC free article] [PubMed]
  • Ring EF. Thermography and rheumatic diseases. Bibl Radiol. 1975;(6):97–106. [PubMed]
  • Ritchie DM, Boyle JA, McInnes JM, Jasani MK, Dalakos TG, Grieveson P, Buchanan WW. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed]
  • PHILIPS VK, ROTHERMICH NO. Local injection of prednisolone TBA in the treatment of rheumatic diseases. Ohio Med. 1957 Jan;53(1):45–46. [PubMed]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Group


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Compound
    PubChem Compound links
  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...