megakaryoblast - PMC

Bethan Psaila, Guanlin Wang, Alba Rodriguez-Meira, Rong Li, Elisabeth F. Heuston, Lauren Murphy, Daniel Yee, Ian S. Hitchcock, Nikolaos Sousos, Jennifer O’Sullivan, Stacie Anderson, Yotis A. Senis, Olga K. Weinberg, Monica L. Calicchio, NIH Intramural Sequencing Center, Deena Iskander, Daniel Royston, Dragana Milojkovic, Irene Roberts, David M. Bodine, Supat Thongjuea, Adam J. Mead

Mol Cell. 2020 May 7; 78(3): 477–492.e8. doi: 10.1016/j.molcel.2020.04.008

PMCID:: PMC7217381

Article

Select item 48846344.

The effect of amifostine on differentiation of the human megakaryoblastic Dami cell line

Hai‐tao Wang, Bo Yang, Bo Hu, Xiao‐hua Chi, Long‐long Luo, Hong‐qi Yang, Xiao‐ling Lang, Jing Geng, Chun‐xia Qiao, Yan Li, Xiao‐Xiong Wu, Hong‐li Zhu, Ming Lv, Xue‐chun Lu

Cancer Med. 2016 Aug; 5(8): 2012–2021. Published online 2016 May 26. doi: 10.1002/cam4.759

PMCID:: PMC4884634

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PKC-epsilon deficiency alters progenitor cell populations in favor of megakaryopoiesis

John C. Kostyak, Elisabetta Liverani, Satya P. Kunapuli

PLoS One. 2017; 12(8): e0182867. Published online 2017 Aug 4. doi: 10.1371/journal.pone.0182867

PMCID:: PMC5544228

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Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs

Masamitsu Sone, Sou Nakamura, Sachiko Umeda, Harumi Ginya, Motohiko Oshima, Maria Alejandra Kanashiro, Sudip Kumar Paul, Kanae Hashimoto, Emiri Nakamura, Yasuo Harada, Kyoko Tsujimura, Atsunori Saraya, Tomoyuki Yamaguchi, Naoshi Sugimoto, Akira Sawaguchi, Atsushi Iwama, Koji Eto, Naoya Takayama

Stem Cell Reports. 2021 Dec 14; 16(12): 2861–2870. Published online 2021 Dec 2. doi: 10.1016/j.stemcr.2021.11.001

PMCID:: PMC8693651

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Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation

Elenoe C. Smith, Alexandra M. Teixeira, Rachel C. Chen, Lin Wang, Yuan Gao, Katherine L. Hahn, Diane S. Krause

Blood. 2013 Feb 14; 121(7): 1094–1101. Prepublished online 2012 Dec 14. doi: 10.1182/blood-2012-05-429993

PMCID:: PMC3575755

Article

Select item 99610758.

The Application of Ethnomedicine in Modulating Megakaryocyte Differentiation and Platelet Counts

Fei Yang, Jia Lai, Junzhu Deng, Jun Du, Xi Du, Xiaoqin Zhang, Yiwei Wang, Qianqian Huang, Qian Xu, Gang Yang, Yanjun Zhang, Xilan Zhou, Xiao Zhang, Yuan Yuan, Chunxiang Zhang, Jianming Wu

Int J Mol Sci. 2023 Feb; 24(4): 3168. Published online 2023 Feb 5. doi: 10.3390/ijms24043168

PMCID:: PMC9961075

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PHENOTYPIC AND FUNCTIONAL COMPARISON OF MOBILIZED PERIPHERAL BLOOD VERSUS UMBILICAL CORD BLOOD MEGAKARYOCYTE POPULATIONS

Joshua Kellner, Sufang Li, Patrick A. Zweidler-McKay, Elizabeth J. Shpall, Ian McNiece

Cytotherapy. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Cytotherapy. 2015 Apr; 17(4): 418–427. Published online 2014 Dec 19. doi: 10.1016/j.jcyt.2014.11.004

PMCID:: PMC4357564

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CD45 expression discriminates waves of embryonic megakaryocytes in the mouse

Isabel Cortegano, Natalia Serrano, Carolina Ruiz, Mercedes Rodríguez, Carmen Prado, Mario Alía, Andrés Hidalgo, Eva Cano, Belén de Andrés, María-Luisa Gaspar

Haematologica. 2019 Sep; 104(9): 1853–1865. Prepublished online 2018 Dec 20. doi: 10.3324/haematol.2018.192559

PMCID:: PMC6717566

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Fetal vs adult megakaryopoiesis

Patricia Davenport, Zhi-Jian Liu, Martha Sola-Visner

Blood. 2022 Jun 2; 139(22): 3233–3244. doi: 10.1182/blood.2020009301

PMCID:: PMC9164738

Article

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Ricolinostat promotes the generation of megakaryocyte progenitors from human hematopoietic stem and progenitor cells

Jianan Jiang, Jinhua Qin, Jisheng Li, Xiaosong Lin, Bowen Zhang, Zeng Fan, Lijuan He, Quan Zeng, Wen Yue, Min Zheng, Xuetao Pei, Yanhua Li

Stem Cell Res Ther. 2022; 13: 54. Published online 2022 Feb 5. doi: 10.1186/s13287-022-02722-5

PMCID:: PMC8817546

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Thrombopoietin-independent generation of platelet-like particles from megakaryoblastic cells

Nuntiporn Nunthanasup, Nutpakal Ketprasit, Egarit Noulsri, Attakorn Palasuwan, Valery Combes, Kasem Kulkeaw, Duangdao Palasuwan

Sci Rep. 2023; 13: 22553. Published online 2023 Dec 18. doi: 10.1038/s41598-023-50111-6

PMCID:: PMC10728061

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Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization

Rachelle E. Kosoff, Joseph E. Aslan, John C. Kostyak, Essel Dulaimi, Hoi Yee Chow, Tatiana Y. Prudnikova, Maria Radu, Satya P. Kunapuli, Owen J. T. McCarty, Jonathan Chernoff

Blood. 2015 May 7; 125(19): 2995–3005. Prepublished online 2015 Mar 30. doi: 10.1182/blood-2014-10-604504

PMCID:: PMC4424419

Article

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Megakaryocyte lineage development is controlled by modulation of protein acetylation

Marije Bartels, Anita Govers, Roel Polak, Stephin Vervoort, Ruben van Boxtel, Cornelieke Pals, Marc Bierings, Wouter van Solinge, Toine Egberts, Edward Nieuwenhuis, Michal Mokry, Paul James Coffer

PLoS One. 2018; 13(4): e0196400. Published online 2018 Apr 26. doi: 10.1371/journal.pone.0196400

PMCID:: PMC5919413

Article PDF–2.6M

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Effect of Mesenchymal Stem Cell-derived Microvesicles on Megakaryocytic Differentiation of CD34⁺ Hematopoietic Stem Cells

Sara Aqmasheh, Karim Shamsasenjan, Elham Khalaf Adeli, Aliakbar Movassaghpourakbari, Parvin Akbarzadehlaleh, Davod Pashoutan Sarvar, Hamzeh Timari

Adv Pharm Bull. 2020 Jun; 10(2): 315–322. Published online 2020 Feb 20. doi: 10.34172/apb.2020.038

PMCID:: PMC7191234

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Development of platelet replacement therapy using human induced pluripotent stem cells

Sou Nakamura, Naoshi Sugimoto, Koji Eto

Dev Growth Differ. 2021 Feb; 63(2): 178–186. Published online 2021 Mar 4. doi: 10.1111/dgd.12711

PMCID:: PMC8048793

Article PDF–716K

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Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells

Giovanni Cova, Chiara Taroni, Marie-Céline Deau, Qi Cai, Vincent Mittelheisser, Muriel Philipps, Matthieu Jung, Marie Cerciat, Stéphanie Le Gras, Christelle Thibault-Carpentier, Bernard Jost, Leif Carlsson, Angela M. Thornton, Ethan M. Shevach, Peggy Kirstetter, Philippe Kastner, Susan Chan

J Exp Med. 2021 Oct 4; 218(10): e20202317. Published online 2021 Aug 30. doi: 10.1084/jem.20202317

PMCID:: PMC8406645

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Enabling Large‐Scale Ex Vivo Production of Megakaryocytes from CD34⁺ Cells Using Gas‐Permeable Surfaces

Andres F. Martinez, William M. Miller

Stem Cells Transl Med. 2019 Jul; 8(7): 658–670. Published online 2019 Mar 8. doi: 10.1002/sctm.18-0160

PMCID:: PMC6591548

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New Insights into the Differentiation of Megakaryocytes from Hematopoietic Progenitors

Leila J Noetzli, Shauna L French, Kellie R Machlus

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Jul; 39(7): 1288–1300. Published online 2019 May 2. doi: 10.1161/ATVBAHA.119.312129

PMCID:: PMC6594866

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PMC Images search for megakaryoblast

Figure 8

Megakaryocytes in megakaryocytic leukemia. (A) A well-developed megakaryoblast 12 μm in diameter containing a small nucleus, undeveloped DMS, and few pro-platelets in the cytoplasm, ×5k. (B) The reactivity of platelet peroxidase in a well-differentiated megakaryoblast, ×5k. (C) A well-developed megakaryoblast including aberrant DMS on 1 side of the cell but few isolated pro-platelets, ×3k. (D) Higher magnification view showing aberrant DMS and dense core granules (arrows) in (C), ×20k.

Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases

Blood Sci. 2021 Oct;3(4):107-112.
Figure 7

Megakaryoblasts in megakaryocytic leukemia. (A) An undifferentiated megakaryoblast with a small cytoplasmic volume containing less DMS and fewer granules in the cytoplasm, ×5k. (B) A poorly differentiated megakaryoblast is characterized by expanded Golgi bodies and primary DMS, but fewer granules in the cytoplasm, ×5k. (C) A megakaryoblast includes a huge nucleus and a few lipid droplets but few organelles, ×15k. (D) Two differentiated megakaryoblasts showing prominent nuclear segmentation and primary DMS (arrowheads); N, neutrophils, ×3k.

Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases

Blood Sci. 2021 Oct;3(4):107-112.
Figure 2

Megakaryoblast with platelet budding (1000X).

Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases

Adv Hematol. 2009;2009:461912.
Figure 1

Megakaryoblast with cytoplasmic blebbing (1000X).

Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases

Adv Hematol. 2009;2009:461912.