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Select item 81867711.

Mycobacterium leprae transmission characteristics during the declining stages of leprosy incidence: A systematic review

Thomas Hambridge, Shri Lak Nanjan Chandran, Annemieke Geluk, Paul Saunderson, Jan Hendrik Richardus

PLoS Negl Trop Dis. 2021 May; 15(5): e0009436. Published online 2021 May 26. doi: 10.1371/journal.pntd.0009436

PMCID:: PMC8186771

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Understanding leprosy reactions and the impact on the lives of people affected: An exploration in two leprosy endemic countries

Annisa Ika Putri, Kevin de Sabbata, Regitta I. Agusni, Medhi Denisa Alinda, Joydeepa Darlong, Barbara de Barros, Stephen L. Walker, Marjolein B. M. Zweekhorst, Ruth M. H. Peters

PLoS Negl Trop Dis. 2022 Jun; 16(6): e0010476. Published online 2022 Jun 13. doi: 10.1371/journal.pntd.0010476

PMCID:: PMC9191760

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Select item 92233143.

Associated factors study into the belated screening for leprosy in Benin

Ronald Sètondji Gnimavo, Ghislain Emmanuel Sopoh, Parfait Djossou, Esaï Gimatal Anagonou, Gilbert Adjimon Ayélo, Anita Carolle Akpéédjé Wadagni, Yves Thierry Barogui, Jean Gabin Houezo, Roch Christian Johnson

PLoS Negl Trop Dis. 2022 Jun; 16(6): e0010533. Published online 2022 Jun 23. doi: 10.1371/journal.pntd.0010533

PMCID:: PMC9223314

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Select item 81822294.

Blood RNA signature RISK4LEP predicts leprosy years before clinical onset

Maria Tió-Coma, Szymon M. Kiełbasa, Susan J.F. van den Eeden, Hailiang Mei, Johan Chandra Roy, Jacco Wallinga, Marufa Khatun, Sontosh Soren, Abu Sufian Chowdhury, Khorshed Alam, Anouk van Hooij, Jan Hendrik Richardus, Annemieke Geluk

EBioMedicine. 2021 Jun; 68: 103379. Published online 2021 Jun 3. doi: 10.1016/j.ebiom.2021.103379

PMCID:: PMC8182229

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Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review

Louise Pierneef, Anouk van Hooij, Anneke Taal, Raisa Rumbaut, Mauricio Lisboa Nobre, Wim van Brakel, Annemieke Geluk

PLoS Negl Trop Dis. 2021 Aug; 15(8): e0009667. Published online 2021 Aug 27. doi: 10.1371/journal.pntd.0009667

PMCID:: PMC8428563

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Select item 61739276.

An enhanced regimen as post-exposure chemoprophylaxis for leprosy: PEP++

Liesbeth F Mieras, Anna T Taal, Wim H van Brakel, Emmanuelle Cambau, Paul R Saunderson, W Cairns S Smith, Cita Rosita S Prakoeswa, Linda Astari, David M Scollard, Dejair Caitano do Nascimento, Jacques Grosset, Hemanta K Kar, Shinzo Izumi, Laura Gillini, Marcos C L Virmond, Marieke G G Sturkenboom

BMC Infect Dis. 2018; 18: 506. Published online 2018 Oct 5. doi: 10.1186/s12879-018-3402-4

PMCID:: PMC6173927

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Active search strategies, clinicoimmunobiological determinants and training for implementation research confirm hidden endemic leprosy in inner São Paulo, Brazil

Fred Bernardes Filho, Claudia Maria Lincoln Silva, Glauber Voltan, Marcel Nani Leite, Ana Laura Rosifini Alves Rezende, Natália Aparecida de Paula, Josafá Gonçalves Barreto, Norma Tiraboschi Foss, Marco Andrey Cipriani Frade

PLoS Negl Trop Dis. 2021 Jun; 15(6): e0009495. Published online 2021 Jun 14. doi: 10.1371/journal.pntd.0009495

PMCID:: PMC8224878

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Community knowledge, perceptions and attitudes regarding leprosy in rural Cameroon: The case of Ekondotiti and Mbonge health districts in the South-west Region

Earnest Njih Tabah, Dickson Shey Nsagha, Anne-Cécile Zoung-Kanyi Bissek, Theophilus Ngeh Njamnshi, Irine Ngani-Nformi Njih, Gerd Pluschke, Alfred Kongnyu Njamnshi

PLoS Negl Trop Dis. 2018 Feb; 12(2): e0006233. Published online 2018 Feb 12. doi: 10.1371/journal.pntd.0006233

PMCID:: PMC5825164

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Longitudinal assessment of anti-PGL-I serology in contacts of leprosy patients in Bangladesh

Renate A. Richardus, Konrad van der Zwet, Anouk van Hooij, Louis Wilson, Linda Oskam, Roel Faber, Susan J. F. van den Eeden, David Pahan, Khorshed Alam, Jan Hendrik Richardus, Annemieke Geluk

PLoS Negl Trop Dis. 2017 Dec; 11(12): e0006083. Published online 2017 Dec 11. doi: 10.1371/journal.pntd.0006083

PMCID:: PMC5746281

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The role of perceptions and knowledge of leprosy in the elimination of leprosy: A baseline study in Fatehpur district, northern India

Anna T. van ‘t Noordende, Ida J. Korfage, Suchitra Lisam, Mohammed A. Arif, Anil Kumar, Wim H. van Brakel

PLoS Negl Trop Dis. 2019 Apr; 13(4): e0007302. Published online 2019 Apr 5. doi: 10.1371/journal.pntd.0007302

Correction in:: PLoS Negl Trop Dis. 2022 Jun; 16(6): e0010519.

PMCID:: PMC6469810

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Select item 840963311.

Innovative tracking, active search and follow-up strategies for new leprosy cases in the female prison population

Claudia Maria Lincoln Silva, Fred Bernardes Filho, Glauber Voltan, Jaci Maria Santana, Marcel Nani Leite, Filipe Rocha Lima, Luisiane de Avila Santana, Natália Aparecida de Paula, Patricia Toscano Barreto Nogueira Onofre, Wilson Marques-Junior, Vanessa Aparecida Tomaz, Carmem Sílvia Vilela Pinese, Marco Andrey Cipriani Frade

PLoS Negl Trop Dis. 2021 Aug; 15(8): e0009716. Published online 2021 Aug 20. doi: 10.1371/journal.pntd.0009716

PMCID:: PMC8409633

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Select item 798650812.

Geospatial epidemiology of leprosy in northwest Bangladesh: a 20-year retrospective observational study

Caroline A. Bulstra, David J. Blok, Khorshed Alam, C. Ruth Butlin, Johan Chandra Roy, Bob Bowers, Peter Nicholls, Sake J. de Vlas, Jan Hendrik Richardus

Infect Dis Poverty. 2021; 10: 36. Published online 2021 Mar 22. doi: 10.1186/s40249-021-00817-4

PMCID:: PMC7986508

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Development of a questionnaire to determine the case detection delay of leprosy: A mixed-methods cultural validation study

Naomi D. de Bruijne, Kedir Urgesa, Abraham Aseffa, Kidist Bobosha, Anne Schoenmakers, Robin van Wijk, Thomas Hambridge, Mitzi M. Waltz, Christa Kasang, Liesbeth Mieras

PLoS Negl Trop Dis. 2022 Jan; 16(1): e0010038. Published online 2022 Jan 13. doi: 10.1371/journal.pntd.0010038

PMCID:: PMC8758092

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Development and validation of a scale to assess attitudes of health care providers towards persons affected by leprosy in southern India

Govindarajulu Srinivas, Shuba Kumar, Rani Mohanraj, Geethalakshmi Sekkizhar, Thirumugam Muthuvel, Vivek Lal, Burkard Koemm, Christa Kasang

PLoS Negl Trop Dis. 2018 Sep; 12(9): e0006808. Published online 2018 Sep 25. doi: 10.1371/journal.pntd.0006808

PMCID:: PMC6177202

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Select item 867066415.

A comparison of three types of targeted, community-based methods aimed at promoting early detection of new leprosy cases in rural parts of three endemic states in India

Karthikeyan Govindasamy, Annamma S. John, Vivek Lal, Mohammad Arif, Raju Moturu Solomon, Jyoti Ghosal, Ambarish Dutta

PLoS One. 2021; 16(12): e0261219. Published online 2021 Dec 14. doi: 10.1371/journal.pone.0261219

PMCID:: PMC8670664

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Select item 775780416.

Polymorphisms in mitochondrial ribosomal protein S5 (MRPS5) are associated with leprosy risk in Chinese

Yan Xing, Jun He, Yan Wen, Jian Liu, Yuangang You, Xiaoman Weng, Lianchao Yuan, Li Xiong, Xiaohua Chen, Ying Zhang, Huan-Ying Li

PLoS Negl Trop Dis. 2020 Dec; 14(12): e0008883. Published online 2020 Dec 23. doi: 10.1371/journal.pntd.0008883

PMCID:: PMC7757804

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Select item 962441117.

Genome-wide association study of leprosy in Malawi and Mali

James J. Gilchrist, Kathryn Auckland, Tom Parks, Alexander J. Mentzer, Lily Goldblatt, Vivek Naranbhai, Gavin Band, Kirk A. Rockett, Ousmane B. Toure, Salimata Konate, Sibiri Sissoko, Abdoulaye A. Djimdé, Mahamadou A. Thera, Ogobara K. Doumbo, Samba Sow, Sian Floyd, Jörg M. Pönnighaus, David K. Warndorff, Amelia C. Crampin, Paul E. M. Fine, Benjamin P. Fairfax, Adrian V. S. Hill

PLoS Pathog. 2022 Sep; 18(9): e1010312. Published online 2022 Sep 19. doi: 10.1371/journal.ppat.1010312

PMCID:: PMC9624411

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Select item 817631318.

Predictive nomogram for leprosy using genetic and epidemiological risk factors in Southwestern China: Case–control and prospective analyses

Si-Yu Long, Ji-Ya Sun, Le Wang, Heng Long, Hai-Qin Jiang, Ying Shi, Wen-Yue Zhang, Jing-Shu Xiong, Pei-Wen Sun, Yan-Qing Chen, You-Ming Mei, Chun Pan, Zhen-Zhen Wang, Zi-Wei Wu, Ai-Ping Wu, Mei-Wen Yu, Hong-Sheng Wang

EBioMedicine. 2021 Jun; 68: 103408. Published online 2021 May 26. doi: 10.1016/j.ebiom.2021.103408

PMCID:: PMC8176313

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Select item 688459819.

Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study

Maria Tió-Coma, Anouk van Hooij, Kidist Bobosha, Jolien J. van der Ploeg-van Schip, Sayera Banu, Saraswoti Khadge, Pratibha Thapa, Chhatra B. Kunwar, Isabela M. Goulart, Yonas Bekele, Deanna A. Hagge, Milton O. Moraes, Rosane M. B. Teles, Roberta Olmo Pinheiro, Erik W. van Zwet, Jelle J. Goeman, Abraham Aseffa, Mariëlle C. Haks, Tom H. M. Ottenhoff, Robert L. Modlin, Annemieke Geluk

Sci Rep. 2019; 9: 17931. Published online 2019 Nov 29. doi: 10.1038/s41598-019-54213-y

PMCID:: PMC6884598

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Select item 759848320.

Patients with skin smear positive leprosy in Bangladesh are the main risk factor for leprosy development: 21-year follow-up in the household contact study (COCOA)

Emily E. V. Quilter, C. Ruth Butlin, Surendra Singh, Khorshed Alam, Diana N. J. Lockwood

PLoS Negl Trop Dis. 2020 Oct; 14(10): e0008687. Published online 2020 Oct 30. doi: 10.1371/journal.pntd.0008687

PMCID:: PMC7598483

Article PDF–453K

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Fig. 1: anti-natural disaccharide linked to human serum albumin via octyl (anti-NDOHSA), anti-Leprosy Infectious Disease Research Institute Diagnostic-1 (anti-LID-1), and anti-natural disaccharide octyl - Leprosy Infectious Disease Research Institute Diagnostic-1 (anti-NDOLID) enzyme-linked immunosorbent assay (ELISA) indexes of leprosy cases according to treatment status and of household contacts. Each point in the figure corresponds to the ELISA index (EI) value of a participant. The median EI for each antigen is represented by a continuous horizontal line. The horizontal dashed line represents the positive cutoff (EI > 1.1). (A) NDOHSA. Mann-Whitney U-test with Bonferroni correction: leprosy cases in treatment versus leprosy cases that had completed treatment (p < 0.0001); leprosy cases in treatment versus household contacts (p < 0.0001); leprosy cases that had completed treatment versus household contacts (p = 0.011). (B) NDOLID. Mann-Whitney U-test with Bonferroni correction: leprosy cases in treatment versus leprosy cases that had completed treatment (p < 0.0001); leprosy cases in treatment versus household contacts (p < 0.0001); leprosy cases that had completed treatment versus household contacts (p = 0.001). (C) LID-1. Mann-Whitney U-test with Bonferroni correction: leprosy cases in treatment versus leprosy cases that had completed treatment (p < 0.0001); leprosy cases in treatment versus household contacts (p < 0.0001); leprosy cases that had completed treatment versus household contacts (p < 0.0001).

Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts

Mem Inst Oswaldo Cruz. 2017 Sep;112(9):609-616.
Figure 2

Immunohistochemical patterns of the inflammasome in leprosy skin lesions.
Notes: Note that immunostaining occurs predominantly in immune cells of the granulomatous inflammatory infiltrate representative of the clinical forms LL, I leprosy, and TT leprosy. Immunostaining for NLRP1 in LL (A), I leprosy (B), and TT leprosy (C); for NLRP3 in LL (D), I leprosy (E), and TT leprosy (F); for caspase 1 in LL (G), I leprosy (H), and TT leprosy (I); for IL-1β in LL (J), I leprosy (K), and TT leprosy (L); and for IL-18 in LL (M), I leprosy (N), and TT leprosy (O). The arrows indicate the stained areas bounded by brownish color coincident with the cell bodies in the granulomatous inflammatory infiltrate (magnification, 200×).
Abbreviations: I, indeterminate; LL, lepromatous leprosy; NLRP1, nucleotide-binding oligomerization domain-like receptor containing pyrin domain 1; NLRP3, nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3; TT, tuberculoid.

The inflammasome in leprosy skin lesions: an immunohistochemical evaluation

Infect Drug Resist. 2018;11:2231-2240.
Fig. 2

Nomogram predicting leprosy probability in leprosy contacts and its predictive performance. a, to use the nomogram, an individual leprosy contact's value is located on each variable axis, and a line is drawn upward to determine the number of points received for each variable value. The sum of these numbers is located on the Total Points axis, and a line is drawn downward to the Risk of Leprosy axes to determine the leprosy probability. b, calibration curve of the nomogram prediction in the training cohort; c, calibration curve of the nomogram prediction in the validation cohort. The actual leprosy proportion is plotted on the y-axis; nomogram predicted probability is plotted on the x-axis. Model performance is shown by the Apparent line, relative to the 45-degree line, which represents perfect prediction. TT, Tuberculoid Leprosy; BT, Borderline tuberculoid Leprosy; BB, Mid-borderline Leprosy; BL, Borderline lepromatous Leprosy; LL, Lepromatous Leprosy; I, Indeterminate Leprosy.

Predictive nomogram for leprosy using genetic and epidemiological risk factors in Southwestern China: Case–control and prospective analyses

EBioMedicine. 2021 Jun;68:103408.
Fig. 1: Clinical spectrum of leprosy. CMI = cell-mediated immunity, TT = tuberculoid leprosy, BT = borderline tuberculoid leprosy, BB = borderline leprosy, BL = borderline lepromatous leprosy, LL = lepromatous leprosy.

Leprosy: a primer for Canadian physicians

CMAJ. 2004 Jan 6;170(1):71-78.