PMC

(a) Fibromuscular obliteration by α-smooth muscle myosin observed around the pyloric glands in the background mucosa surrounding the lesion; in places, this extends as if to support the foveolar epithelium. (b) Inside the lesion, fibromuscular obliteration seems to support the foveolar epithelium. (c) Schema representing fibromuscular obliteration. Fibromuscular obliteration is surrounded by blue paint.

ARCADIA indicates Assessment of Renal and Cervical Artery Dysplasia; European/International Registry, European/International FMD Registry; OR, odds ratio; and US FMD Registry, US Registry for Fibromuscular Dysplasia.

Photomicrographs of prostate glands of experimental groups after 21 days of treatment: (a) model; (b) low dose of oil (30 mg/kg); (c) mid-dose of oil (100 mg/kg); (d) high dose of oil (300 mg/kg); (e) finasteride (15 mg/kg); (f) normal control. Prostatic secretions (S), epithelium (EP), and fibromuscular stroma (FS), model group had larger acini with thicker epithelium, more prostatic secretions, and thinner fibromuscular stroma. Low dose group had slightly large acini, light prostatic secretions and thin fibromuscular stroma. Mid-dose group shows smaller acini with thinner epithelium, moderate prostatic secretion, thick strand of the fibromuscular stroma. High-dose group shows small-sized acini, moderate prostatic secretions, thin epithelium and thick fibromuscular stroma. Finasteride group had almost absent prostatic secretions and a very few amount of fibromuscular stroma, sham group had small-sized acini, little or no prostatic secretion, together with few strands of the fibromuscular stroma.

Immunohistochemical analysis of ER- α imunostaining of xenograft tumors the mammary gland fibromuscular stroma consecutive sections in different mice groups. The xenografted tumors were harvested and immunostained with the anti-ERα antibody. (A)—MCF-7 xenograft: A photomicrograph of a section in the mammary gland of the control group showing a strong ERα -positive nuclear and/or cytoplasmic immunoreaction in the form of a brown color in the cells of the fibromuscular stroma. (B)—MCF-7 xenograft/DOX: A photomicrograph of a section in the mammary gland of DOX treated group was apparently slightly same intense of ERα nuclear and/or cytoplasmic in the cells of the fibromuscular stroma and morphometric analysis of ER-a-positive cells showed a non-significant increase when compared with the control group. (C)—MCF-7 xenograft/CQ: A photomicrograph of a section in the mammary gland of CQ treated group was apparently moderately differentiated tubular tumors and displayed moderate of an ERα nuclear intense and less intense of cytoplasmic ERα in the cells of the fibromuscular stroma compared with the control group, (D)—MCF-7 xenograft/TIC: A photomicrograph of a section in the mammary gland of TIC treated group was apparently moderate differentiated tubular tumors and displayed moderate intense of an ERα nuclear intense and less intense of cytoplasmic ERα in the cells of the fibromuscular stroma compared with the control group. (E)—MCF-7 xenograft/DOX + CQ: A photomicrograph of a section in the mammary gland of DOX/CQ treated group was apparently moderate differentiated tubular tumors and displayed less intense of an ERα nuclear and cytoplasmic intense of ERα in the cells of the fibromuscular stroma compared with the control group. (F)—MCF-7 xenograft/DOX + TIC: A photomicrograph of a section in the mammary gland of DOX/CQ treated group was apparently moderate differentiated tubular tumors and displayed less intense of an ERα nuclear and cytoplasmic intense of ERα in the cells of the fibromuscular stroma compared with the control group. (G)—MCF-7 xenograft/DOX + CQ + TIC: A photomicrograph of a section in the mammary gland of DOX/CQ/TIC treated group was apparently developed poorly differentiated tumors showing almost slightly loss of ERα intense in the cells of the fibromuscular stroma compared with the control group 50 μm.