PMC

Parents were asked: “We would like to know more about how specific tasks that may be part of a Type 1 diabetes clinical trial may influence your decision to enroll your child. How comfortable would you feel if your child were asked to do the following?” Shapes correspond to self-described comfort score on a five-point Likert scale: black square  =  not at all, black circle  =  a little, white triangle  =  some, white circle  =  a great deal, white square  =  completely. The X-axis represents proportion of parents endorsing a specific comfort score. “All Respondents” indicates protocol-specific comfort breakdown for all parents; “Willing to Enroll” indicates protocol-specific comfort breakdown for parents who endorsed they were “completely” or “a great deal” willing to enroll a child with diabetes; “Not Willing to Enroll” indicates protocol-specific comfort breakdown for parents who endorsed they were “not at all” or “a little” willing to enroll a child with diabetes. Breakdown for reponses depending on willingness to enroll an unaffected child are not shown as results are similar. Green box highlights tasks with which >60% of all parents were “a great deal” or “completely” comfortable. The purple box highlights tasks with which <30% of all parents were “a great deal” or “completely” comfortable. Comfort with all protocols surveyed had a statistically significant positive correlation with both willingness to enroll a child with diabetes and a non-affected child (r = 0.23–0.6). This effect can be appreciated above by the larger green and much smaller purple box among parents who reported willingness to enroll their children in T1DCTs.

Overall comparisons of mothers’ willingness to enroll children in research, by personal and children’s health status

Willingness to enroll for community-based health insurance of participant Simada District, Amhara, North West Ethiopia, 2020. (N=510).

Participant ratings of the importance of trial factors in the decision whether to enroll for each racial group. * indicates P < .05 for racial differences.