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Select item 102508021.

Orthostatic chronotropic incompetence in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

C. (Linda) M.C. van Campen, Freek W.A. Verheugt, Peter C. Rowe, Frans C. Visser

IBRO Neurosci Rep. 2023 Dec; 15: 1–10. Published online 2023 May 2. doi: 10.1016/j.ibneur.2023.04.005

PMCID:: PMC10250802

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Select item 108365432.

Chronotropic Incompetence During Exercise Testing as a Marker of Autonomic Dysfunction in Individuals with Early Parkinson’s Disease

Garett Griffith, Guillaume Lamotte, Niyati Mehta, Peng Fan, Juliana Nikolich, Victoria Springman, Erin Suttman, Elizabeth Joslin, Katherine Balfany, MacKenzie Dunlap, Wendy M. Kohrt, Cory L. Christiansen, Edward L. Melanson, Deborah Josbeno, Lana M. Chahine, Charity G. Patterson, Daniel M. Corcos

J Parkinsons Dis. 2024; 14(1): 121–133. Prepublished online 2024 Jan 4. Published online 2024 Jan 23. doi: 10.3233/JPD-230006

PMCID:: PMC10836543

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Select item 106594533.

Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study

Matthew S. Durstenfeld, Melissa P. Wilson, Catherine M. Jankowski, Grace L. Ditzenberger, Chris T. Longenecker, Kristine M. Erlandson

Version 1. medRxiv. Preprint. 2023 Nov 10. doi: 10.1101/2023.11.10.23298367

PMCID:: PMC10659453

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Select item 79204324.

Chronotropic Incompetence Limits Aerobic Exercise Capacity in Patients Taking Beta-Blockers: Real-Life Observation of Consecutive Patients

Krzysztof Smarz, Maciej Tysarowski, Beata Zaborska, Ewa Pilichowska-Paszkiet, Małgorzata Sikora-Frac, Andrzej Budaj, Tomasz Jaxa-Chamiec

Healthcare (Basel) 2021 Feb; 9(2): 212. Published online 2021 Feb 16. doi: 10.3390/healthcare9020212

PMCID:: PMC7920432

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Select item 66767755.

Chronotropic incompetence and myocardial injury after noncardiac surgery: planned secondary analysis of a prospective observational international cohort study

Tom E.F. Abbott, Rupert M. Pearse, W. Scott Beattie, Mandeep Phull, Christian Beilstein, Ashok Raj, Michael P.W. Grocott, Brian H. Cuthbertson, Duminda Wijeysundera, Gareth L. Ackland

Br J Anaesth. 2019 Jul; 123(1): 17–26. Published online 2019 Apr 24. doi: 10.1016/j.bja.2019.03.022

PMCID:: PMC6676775

Article PDF–526K

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Chronotropic Incompetence and Risk of Atrial Fibrillation: The Henry Ford ExercIse Testing (FIT) Project

Wesley T. O’Neal, Waqas T. Qureshi, Michael J. Blaha, Zeina A. Dardari, Jonathan K. Ehrman, Clinton A. Brawner, Elsayed Z. Soliman, Mouaz H. Al-Mallah

JACC Clin Electrophysiol. Author manuscript; available in PMC 2017 Nov 1.

Published in final edited form as: JACC Clin Electrophysiol. 2016 Nov; 2(6): 645–652. doi: 10.1016/j.jacep.2016.03.013

PMCID:: PMC5403158

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Association of SARS‐CoV‐2 Infection and Cardiopulmonary Long COVID With Exercise Capacity and Chronotropic Incompetence Among People With HIV

Matthew S. Durstenfeld, Michael J. Peluso, Matthew A. Spinelli, Danny Li, Rebecca Hoh, Ahmed Chenna, Brandon Yee, John Winslow, Christos Petropoulos, Monica Gandhi, Timothy J. Henrich, Mandar A. Aras, Carlin S. Long, Steven G. Deeks, Priscilla Y. Hsue

J Am Heart Assoc. 2023 Oct; 12(20): e030896. Published online 2023 Oct 17. doi: 10.1161/JAHA.123.030896

PMCID:: PMC10757521

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Select item 67690748.

The Ionotropic P2X4 Receptor has Unique Properties in the Heart by Mediating the Negative Chronotropic Effect of ATP While Increasing the Ventricular Inotropy

Bruno Bragança, Sílvia Nogueira-Marques, Fátima Ferreirinha, Ana Patrícia Fontes-Sousa, Paulo Correia-de-Sá

Front Pharmacol. 2019; 10: 1103. Published online 2019 Sep 24. doi: 10.3389/fphar.2019.01103

PMCID:: PMC6769074

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Temporal Reduction in Chronotropic Index Predicts Risk of Cardiovascular Death Among Healthy Middle‐Aged Men: a 28‐Year Follow‐Up Study

Kristian Engeseth, Christian Hodnesdal, Irene Grundvold, Knut Liestøl, Knut Gjesdal, Sverre E. Kjeldsen, Jan E. Erikssen, Johan Bodegard, Per Torger Skretteberg

J Am Heart Assoc. 2016 Dec; 5(12): e004555. Published online 2016 Nov 23. doi: 10.1161/JAHA.116.004555

PMCID:: PMC5210440

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Select item 642487810.

The Influence of Continuous Exercising on Chronotropic Incompetence in Multi-Episode Schizophrenia

Marco Herbsleb, Katriona Keller-Varady, Thomas Wobrock, Alkomiet Hasan, Andrea Schmitt, Peter Falkai, Holger Horst Werner Gabriel, Karl-Jürgen Bär, Berend Malchow

Front Psychiatry. 2019; 10: 90. Published online 2019 Mar 13. doi: 10.3389/fpsyt.2019.00090

PMCID:: PMC6424878

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Heart rate score, a measure related to chronotropic incompetence in pacemaker patients

Arjun D. Sharma, Mark Richards, Brian Olshansky, Nicholas Wold, Paul Jones, David Perschbacher, Bruce L. Wilkoff

Heart Rhythm O2. 2021 Apr; 2(2): 124–131. Published online 2021 Feb 20. doi: 10.1016/j.hroo.2021.02.002

PMCID:: PMC8183967

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Select item 642286812.

Heart Rate Response During Treadmill Exercise Test in Children and Adolescents With Congenital Heart Disease

Fabian von Scheidt, Stephanie Meier, Johannes Krämer, Anita Apitz, Jannos Siaplaouras, Peter Bride, Michael Kaestner, Christian Apitz

Front Pediatr. 2019; 7: 65. Published online 2019 Mar 12. doi: 10.3389/fped.2019.00065

PMCID:: PMC6422868

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Select item 1023078813.

Evidence for a lack of inotropic and chronotropic effects of glucagon and glucagon receptors in the human heart

Ramón Aranda-Domene, Esteban Orenes-Piñero, José María Arribas-Leal, Sergio Canovas-Lopez, Jesús Hernández-Cascales

Cardiovasc Diabetol. 2023; 22: 128. Published online 2023 May 30. doi: 10.1186/s12933-023-01859-8

PMCID:: PMC10230788

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Select item 591222514.

Can chronotropic incompetence predict life-threatening ventricular arrhythmias in patients with stable ischemic heart disease?

Yelena Rib, Gulnar Zhussupova, Gaukhar Igimbayeva, Ayan Abdrakhmanov, Seyed Farzad Jalali

Caspian J Intern Med. 2018 Spring; 9(2): 164–170. doi: 10.22088/cjim.9.2.164

PMCID:: PMC5912225

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Select item 643947815.

Chronotropic Intolerance: An Overlooked Determinant of Symptoms and Activity Limitation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?

Todd E. Davenport, Mary Lehnen, Staci R. Stevens, J. Mark VanNess, Jared Stevens, Christopher R. Snell

Front Pediatr. 2019; 7: 82. Published online 2019 Mar 22. doi: 10.3389/fped.2019.00082

PMCID:: PMC6439478

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Select item 934273816.

Chronotropic incompetence in end-stage liver disease

Renata Główczyńska, Sonia Borodzicz-Jażdżyk, Michał Peller, Joanna Raszeja-Wyszomirska, Piotr Milkiewicz, Krzysztof Zieniewicz, Grzegorz Opolski

PLoS One. 2022; 17(8): e0270784. Published online 2022 Aug 1. doi: 10.1371/journal.pone.0270784

PMCID:: PMC9342738

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Select item 732231617.

Resting Heart Rate and Chronotropic Response to Exercise: Prognostic Implications in Heart Failure Across the Left Ventricular Ejection Fraction Spectrum

MáRIO SANTOS, ERIN WEST, HICHAM SKALI, DANIEL E. FORMAN, WILSON NADRUZ, Junior, AMIL M. SHAH

J Card Fail. Author manuscript; available in PMC 2020 Jun 29.

Published in final edited form as: J Card Fail. 2018 Nov; 24(11): 753–762. Published online 2018 Oct 6. doi: 10.1016/j.cardfail.2018.09.015

PMCID:: PMC7322316

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Select item 571304118.

Chronotropic Competence Indices Extracted from Wearable Sensors for Cardiovascular Diseases Management

Jiankang Wu, Jianan Li, Andrew Seely, Yi Zhu, Sisi Huang, Xiaoqin Wang, Lei Zhao, Hongliang Wang, Herry Christophe

Sensors (Basel) 2017 Nov; 17(11): 2441. Published online 2017 Oct 25. doi: 10.3390/s17112441

PMCID:: PMC5713041

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Select item 861799219.

Chronotropic Incompetence in Non-Hospitalized Patients with Post-COVID-19 Syndrome

Amaya Jimeno-Almazán, Jesús G. Pallarés, Ángel Buendía-Romero, Alejandro Martínez-Cava, Javier Courel-Ibáñez

J Clin Med. 2021 Nov; 10(22): 5434. Published online 2021 Nov 20. doi: 10.3390/jcm10225434

PMCID:: PMC8617992

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Select item 544528620.

Impaired chronotropic response to physical activities in heart failure patients

Hong Shen, Jianrong Zhao, Xiaohong Zhou, Jingbo Li, Qing Wan, Jing Huang, Hui Li, Liqun Wu, Shungang Yang, Ping Wang

BMC Cardiovasc Disord. 2017; 17: 136. Published online 2017 May 25. doi: 10.1186/s12872-017-0571-9

PMCID:: PMC5445286

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PMC Images search for chronotropic

Fig 2

Kaplan–Meier survival plot for chronotropic incompetence (chronotropic index <0.6) vs no chronotropic incompetence (chronotropic index ≥0.6).

Chronotropic incompetence and myocardial injury after noncardiac surgery: planned secondary analysis of a prospective observational international cohort study

Br J Anaesth. 2019 Jul;123(1):17-26.
Figure 2Unadjusted Cumulative Incidence of Atrial Fibrillation with Varying Chronotropic Incompetence Cut-off Points*

*Chronotropic incompetence was defined using age-predicted maximum heart rate.

Chronotropic Incompetence and Risk of Atrial Fibrillation: The Henry Ford ExercIse Testing (FIT) Project

JACC Clin Electrophysiol. ;2(6):645-652.
Figure 1Unadjusted Cumulative Incidence of Atrial Fibrillation by Chronotropic Incompetence*

*Chronotropic incompetence was defined as <85% of the age-predicted maximum heart rate. Cumulative incidence curves are statistically different (log-rank p<0.0001).

Chronotropic Incompetence and Risk of Atrial Fibrillation: The Henry Ford ExercIse Testing (FIT) Project

JACC Clin Electrophysiol. ;2(6):645-652.
Figure 1

The relationship between chronotropic index and probability of all-cause mortality at 2-year follow-up. The figure shows a significantly non-linear relationship between chronotropic index and all-cause mortality. The risk of event decreases as the chronotropic index goes up, but only until chronotropic index reaches ∼0.6. Above 0.6, the risk is roughly constant, so we assumed a constant hazard above 0.6.

Association between resting heart rate, chronotropic index, and long-term outcomes in patients with heart failure receiving β-blocker therapy: data from the HF-ACTION trial

Eur Heart J. 2013 Aug 1;34(29):2271-2280.