PMC

(A) For every compound, we give the average number of bridging molecules (blue columns) and bridges (red columns) for the four production runs; error bars represent standard deviations. (B) Bridging water–ligand radial distribution functions computed from the four 100 ns production dynamics simulations for every compound. (C) Bridging Na⁺–ligand radial distribution functions computed from the four 100 ns production dynamics simulations for every compound.

The bridging exercises on the 3 surfaces in supine and prone position. (A) normal bridging exercise in supine. (B) bridging with ball exercise in supine. (C) bridging with sling exercise in supine. (D) normal bridging exercise in prone. (E) bridging with ball exercise in prone. (F) bridging with sling exercise in prone.

Number and distribution of bridging interactions. (a) Number of water-, spermine-, and ion-mediated bridging interactions as a function of time in the unmodified Tau system. (b) Number of water-, spermine-, and ion-mediated bridging interactions as a function of time in the phosphorylated Tau system. (c) Distribution of water-, spermine-, and ion-mediated bridging interactions by lifetime (i.e., the duration of the bridging interactions) in the unmodified Tau system. Note that the blue and yellow curves largely overlap and are hard to distinguish. (d) Distribution of water-, spermine-, and ion-mediated bridging interactions by lifetime (i.e., the duration of the bridging interactions) in the phosphorylated Tau system. (e) Number of water- and ion-mediated bridging interactions as a function of time in the unmodified Tau system without spermine. (f) Number of water- and ion-mediated bridging interactions as a function of time in the phosphorylated Tau system without spermine. (g) Distribution of water- and ion-mediated bridging interactions by lifetime (i.e., the duration of the bridging interactions) in the unmodified Tau system without spermine. (h) Distribution of water- and ion-mediated bridging interactions by lifetime (i.e., the duration of the bridging interactions) in the phosphorylated Tau system without spermine.

The 8 types of posterior lumbar interbody fusion according to morphological CT characteristics. Type 1: Unilateral intra-cage; trabecular bone bridging between 2 adjacent vertebral bodies is observed inside the unilateral cage on CT coronal view. Type 2: Bilateral intra-cage; bone bridging is observed inside both cages. Type 3: Unilateral intra-cage with ipsilateral lateral bridging of extra-cage; bone bridging is observed between the area inside the unilateral cage and the lateral space outside the cage. Type 4: Bilateral intra-cage with unilateral lateral bridging of extra-cage; bone bridging is observed between the bilateral areas inside the both cages and the lateral space outside the unilateral cage. Type 5: Bilateral intra-cage with bilateral lateral bridging of extra-cage; bone bridging is observed between the inside of both cages and each lateral space outside the cages. Type 6: interspace bridging of 2 cages only; bone bridging is observed only in the space between the 2 cages. Type 7: bilateral intra-cage with interspace bridging of 2 cages; bone bridging is observed between the areas inside both cages and the space between the 2 cages. Type 8: Complete fusion; bone bridging is observed in all spaces inside and outside of the 2 cages. CT = computed tomography.