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Select item 92313441.

Review on the Pharmacological Properties of Phillyrin

Chenyu Zhou, Mengya Lu, Jialei Cheng, Emelda Rosseleena Rohani, Hamizah Shahirah Hamezah, Rongchun Han, Xiaohui Tong

Molecules. 2022 Jun; 27(12): 3670. Published online 2022 Jun 7. doi: 10.3390/molecules27123670

PMCID:: PMC9231344

Article PDF–673K

Select item 75763582.

Phillyrin Mitigates Apoptosis and Oxidative Stress in Hydrogen Peroxide-Treated RPE Cells through Activation of the Nrf2 Signaling Pathway

Yuanyuan Du, Longtai You, Boran Ni, Na Sai, Wenping Wang, Mingyi Sun, Rui Xu, Yu Yao, Zhiqin Zhang, Changhai Qu, Xingbin Yin, Jian Ni

Oxid Med Cell Longev. 2020; 2020: 2684672. Published online 2020 Oct 12. doi: 10.1155/2020/2684672

Correction in:: Oxid Med Cell Longev. 2023; 2023: 9891240.

PMCID:: PMC7576358

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Select item 106446263.

Phillyrin ameliorates influenza a virus-induced pulmonary inflammation by antagonizing CXCR2 and inhibiting NLRP3 inflammasome activation

Shanyu Zhang, Fengzhi Sun, Jinlu Zhu, Jianhong Qi, Wenjing Wang, Ziming Liu, Wenqian Li, Chuanguo Liu, Xuehuan Liu, Nonghan Wang, Xinyu Song, Dan Zhang, Dongmei Qi, Xiaolong Wang

Virol J. 2023; 20: 262. Published online 2023 Nov 13. doi: 10.1186/s12985-023-02219-4

PMCID:: PMC10644626

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Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified

Lu-lu Pan, Yong Yang, Min Hui, Shuo Wang, Cui-yun Li, Hong Zhang, Yan-hua Ding, Li Fu, Xing-xing Diao, Da-fang Zhong

Acta Pharmacol Sin. 2021 Feb; 42(2): 311–322. Published online 2020 Aug 28. doi: 10.1038/s41401-020-0481-8

PMCID:: PMC8026975

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Protective effect of phillyrin against cerebral ischemia/reperfusion injury in rats and oxidative stress-induced cell apoptosis and autophagy in neurons

Shu Chen, Shan Zhang, Honggang Wu, Daobao Zhang, Guoliang You, Jing You, Niandong Zheng

Bioengineered. 2022; 13(3): 7940–7950. Published online 2022 Mar 16. doi: 10.1080/21655979.2022.2042142

PMCID:: PMC9278963

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Downregulating PDPK1 and taking phillyrin as PDPK1-targeting drug protect hepatocytes from alcoholic steatohepatitis by promoting autophagy

Yuan Zhang, Yuhao Ding, Huizi Zhao, Zhonghao Wang, Fanle Zeng, Zhenzhen Qian, Jun Li, Taotao Ma, Cheng Huang

Cell Death Dis. 2022 Nov; 13(11): 991. Published online 2022 Nov 23. doi: 10.1038/s41419-022-05422-3

PMCID:: PMC9684571

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Select item 96109527.

Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a β-Cyclodextrin-Assisted Method

Jing Li, Qiao Qin, Sheng-Hua Zha, Qing-Sheng Zhao, Hang Li, Lu-Peng Liu, Shou-Bu Hou, Bing Zhao

Molecules. 2022 Oct; 27(20): 7055. Published online 2022 Oct 19. doi: 10.3390/molecules27207055

PMCID:: PMC9610952

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Select item 64519188.

Phillyrin is an effective inhibitor of quorum sensing with potential as an anti-Pseudomonas aeruginosa infection therapy

Shuxin ZHOU, An ZHANG, Weihua CHU

J Vet Med Sci. 2019 Mar; 81(3): 473–479. Published online 2019 Jan 28. doi: 10.1292/jvms.18-0523

PMCID:: PMC6451918

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The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance

Xiaoqing Xu, Fatma S. A. Saadeldeen, Lanting Xu, Yingying Zhao, Jinfeng Wei, Hui-Min David Wang, Zhenhua Liu, Wenyi Kang

Biomed Res Int. 2019; 2019: 3176483. Published online 2019 Jul 2. doi: 10.1155/2019/3176483

PMCID:: PMC6634060

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Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling

Da-hua Wang, Xi He, Qing He

Biosci Rep. 2019 Jun 28; 39(6): BSR20190459. Prepublished online 2019 May 29. Published online 2019 Jun 20. doi: 10.1042/BSR20190459

PMCID:: PMC6616054

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Antiviral effect and mechanism of Phillyrin and its reformulated FS21 against influenza

Yan Chen, Cunjin Wu, Huifen Li, Harrison Powell, Allison Chen, Guodong Zhu, Weihong Cong, Li Fu, Andrew Pekosz, Sean X. Leng

Influenza Other Respir Viruses. 2023 Mar; 17(3): e13112. Published online 2023 Mar 1. doi: 10.1111/irv.13112

PMCID:: PMC9975791

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Optimization of Ultrasonic-Assisted Simultaneous Extraction of Three Active Compounds from the Fruits of Forsythia suspensa and Comparison with Conventional Extraction Methods

Xinsheng Fang, Shubo Gu, Zongyuan Jin, Mingqian Hao, Zhenzhen Yin, Jianhua Wang

Molecules. 2018 Sep; 23(9): 2115. Published online 2018 Aug 23. doi: 10.3390/molecules23092115

PMCID:: PMC6225468

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Phillyrin Relieves Lipopolysaccharide-Induced AKI by Protecting Against Glycocalyx Damage and Inhibiting Inflammatory Responses

Dong Zhang, Boyang Qi, Dongxiao Li, Jiali Feng, Xiao Huang, Xiaohong Ma, Lina Huang, Xiaozhi Wang, Xiangyong Liu

Inflammation. 2020; 43(2): 540–551. Published online 2019 Dec 12. doi: 10.1007/s10753-019-01136-5

PMCID:: PMC7095384

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Select item 958127114.

Phillyrin restores metabolic disorders in mice fed with high-fat diet through inhibition of interleukin-6-mediated basal lipolysis

Zhizheng Fang, Lu Wei, Yanping Lv, Tongsheng Wang, Hamizah Shahirah Hamezah, Rongchun Han, Xiaohui Tong

Front Nutr. 2022; 9: 956218. Published online 2022 Oct 5. doi: 10.3389/fnut.2022.956218

PMCID:: PMC9581271

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Select item 1083627715.

Safety, tolerability and pharmacokinetics of forsythin in healthy subjects: a double-blinded, placebo-controlled single-dose and multiple-dose escalation and food effect study

Cuiyun Li, Min Wu, Hong Zhang, Xiaoxue Zhu, Li Fu, Shuo Wang, Mingming Lu, Dafang Zhong, Yanhua Ding

Ann Med. 2023; 55(2): 2274512. Published online 2023 Nov 19. doi: 10.1080/07853890.2023.2274512

PMCID:: PMC10836277

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Select item 969487016.

Comparative Transcriptome Analysis of MeJA Responsive Enzymes Involved in Phillyrin Biosynthesis of Forsythia suspensa

Xiaoran Liu, Jiaqi Zhang, Hao Liu, Huixiang Shang, Xingli Zhao, Huawei Xu, Hongxiao Zhang, Dianyun Hou

Metabolites. 2022 Nov; 12(11): 1143. Published online 2022 Nov 20. doi: 10.3390/metabo12111143

PMCID:: PMC9694870

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Select item 627218117.

Comparison of Fruits of Forsythia suspensa at Two Different Maturation Stages by NMR-Based Metabolomics

Jinping Jia, Fusheng Zhang, Zhenyu Li, Xuemei Qin, Liwei Zhang

Molecules. 2015 Jun; 20(6): 10065–10081. Published online 2015 May 29. doi: 10.3390/molecules200610065

PMCID:: PMC6272181

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Select item 823307918.

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Zhong Han, Jianmin Guo, Feibiao Meng, Haifeng Liao, Yinghua Deng, Yuankeng Huang, Xialing Lei, Chun Liang, Richou Han, Wei Yang

Evid Based Complement Alternat Med. 2021; 2021: 6610793. Published online 2021 Jun 18. doi: 10.1155/2021/6610793

PMCID:: PMC8233079

Article PDF–459K

Select item 737948619.

Functional Gene Module–Based Identification of Phillyrin as an Anticardiac Fibrosis Agent

Lei Wang, Wuxia Zhang, Ziwen Lu, Baofu Wang, Yang Li, Jingjing Yang, Peng Li, Mingjing Zhao

Front Pharmacol. 2020; 11: 1077. Published online 2020 Jul 17. doi: 10.3389/fphar.2020.01077

PMCID:: PMC7379486

Article PDF–2.6M

Select item 733303720.

Comprehensive Screening and Identification of Phillyrin Metabolites in Rats Based on UHPLC-Q-Exactive Mass Spectrometry Combined with Multi-Channel Data Mining

Beibei Ma, Jiameng Li, Tianyu Lou, Yaoyue Liang, Chenxiao Wang, Ruiji Li, Tingting Wang, Jinhui Liu, Yudong Guo, Zhibin Wang, Jing Wang

Int J Anal Chem. 2020; 2020: 8274193. Published online 2020 Jun 24. doi: 10.1155/2020/8274193

PMCID:: PMC7333037

Article PDF–1.0M

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Figure 1Forsythin is an inhibitor of PDE4.

A–C. The chemical structure of Forsythin extracted from Forsythia suspensa seeds. Forsythin is an o-linked β-D-glucopyranosylated lignin that can be hydrolyzed (Red line). D. Predicted docking site of Forsythin with PDE4. E. Predicted residue electrostatic and van der Waals interactions between PDE4 amino acids and Forsythin. Using ZINCPharmer , a pharmacophore model was generated (upper left) and used to screen the lead compounds from an 18.3 million purchasable compound library.

Novel PDE4 Inhibitors Derived from Chinese Medicine Forsythia

PLoS One. 2014;9(12):e115937.
Fig. 5

Plasma concentration–time profiles of forsythin, M1 (aglycone), M2 (M1 sulfate), and M7 (M1 glucuronide) following administration of 800 mg forsythin capsules in three healthy volunteers.

Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified

Acta Pharmacol Sin. 2021 Feb;42(2):311-322.
Fig. 4

Plasma concentration–time profiles of forsythin, M1 (aglycone), M2 (M1 sulfate), and M7 (M1 glucuronide) following administration of 100 mg forsythin capsules in three healthy volunteers.

Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified

Acta Pharmacol Sin. 2021 Feb;42(2):311-322.
Figure 1

The diagram of forsythin determined by high-performance liquid chromatography-UV (HPLC-UV).

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin

Evid Based Complement Alternat Med. 2021;2021:6610793.