Results: 3

1.
Figure 2

Figure 2. From: Interleukin 6 Dependence of Anti-DNA Antibody Production: Evidence for Two Pathways of Autoantibody Formation in Pristane-induced Lupus .

IgG antichromatin antibody ELISA. Serial serum samples from all pristane- or PBS-treated mice were analyzed at a dilution of 1:500 for IgG anti-chromatin antibodies by ELISA. Levels of IgG antichromatin are expressed in units × 106 (see Materials and Methods).

Hanno B. Richards, et al. J Exp Med. 1998 September 7;188(5):985-990.
2.
Figure 3

Figure 3. From: Interleukin 6 Dependence of Anti-DNA Antibody Production: Evidence for Two Pathways of Autoantibody Formation in Pristane-induced Lupus .

Anti-nRNP/Sm and anti-chromatin antibody ELISAs.Sera from pristane treated IL-6−/− (n = 28, •) or IL-6+/+ (n = 26, ▪) mice and from PBS-treated IL-6−/− (n = 10, ○) or IL-6+/+ (n = 10, □) mice 0–8 mo after treatment were tested for anti-nRNP/Sm (A and B) and antichromatin (C and D) antibodies by ELISA. (Top) Frequencies (%) of sera containing IgG anti-nRNP/Sm (A) or antichromatin (B) autoantibodies (defined as >3 SDs above the mean of negative controls). (Bottom) Levels of anti-nRNP/Sm (B) or anti-chromatin (D) autoantibodies (in units). Data represent the mean of all animals in each group.

Hanno B. Richards, et al. J Exp Med. 1998 September 7;188(5):985-990.
3.

Figure 1. From: Interleukin 6 Dependence of Anti-DNA Antibody Production: Evidence for Two Pathways of Autoantibody Formation in Pristane-induced Lupus .

Anti-ssDNA and anti-dsDNA autoantibody levels. (left) Sera from BALB/cAn IL-6−/− or IL-6+/+ mice 3 wk after pristane or PBS treatment were tested by ELISA for IgM anti-ssDNA antibodies at a dilution of 1:500. Sera from the same mice 8 mo after treatment were tested by ELISA for IgG anti-ssDNA antibodies. Symbols represent individual animals and horizontal lines represent the mean A405 nm of each group (*P < 0.005 in the IL-6+/+ pristane versus IL-6−/− pristane by Mann Whitney test). (right) Sera from BALB/cAn mice 8 mo after pristane or PBS treatment, 5-mo-old MRL/lpr mice, and mAb 6/O2 576-2 (IgG anti-ssDNA) were analyzed by ELISA for IgG anti-dsDNA antibodies at a 1:160 dilution. Samples were negative (•) or positive (□) positive by Crithidia assay at a 1:40 dilution.

Hanno B. Richards, et al. J Exp Med. 1998 September 7;188(5):985-990.

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