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1.
Figure 6

Figure 6. ERG changes as a function of age in GHL+ and GHL+/Chop−/− mice.. From: Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa.

Maximal a- and b-wave amplitudes as a function of age in C57BL/6 (blue trace), Chop−/− (orange trace) GHL+ (black trace) and GHL+/Chop−/− (red trace) mice. Colored lines are polynomial fits.

Adeseye Adekeye, et al. PLoS One. 2014;9(2):e83871.
2.
Figure 9

Figure 9. Rate of retinal degeneration in GHL+ and GHL+/Ask1−/− mice.. From: Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa.

Maximal a- and b-wave amplitudes as a function of age in C57BL/6 (blue), Ask1−/− (green) GHL+ (black) and GHL+/Ask1−/− (purple) mice. Error bars: ± SD. Colored lines are polynomial fits.

Adeseye Adekeye, et al. PLoS One. 2014;9(2):e83871.
3.
Figure 8

Figure 8. ERG responses in GHL+ and GHL+/Ask1−/− mice.. From: Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa.

Intensity-response functions of a- and b-waves in (A) 4, (B) 16, and (C) 28 week old C57BL/6 (blue), Ask1−/− (green) GHL+ (black) and GHL+/Ask1−/− (purple) mice (n = 7–14). Error bars: ± SD.

Adeseye Adekeye, et al. PLoS One. 2014;9(2):e83871.
4.
Figure 7

Figure 7. Age related changes in retinal function and sensitivity of GHL+ and GHL+/Chop−/− mice.. From: Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa.

(A) b/a wave ratio in C57BL/6, Chop−/−, GHL+, and GHL+/Chop−/− mice. (B and C) Age related changes in a- and b-wave threshold intensities in C57BL/6, Chop−/−, GHL+, and GHL+/Chop−/− mice (a- wave It = 50 µV, b- wave It = 75 µV). Error bars: ± SD.

Adeseye Adekeye, et al. PLoS One. 2014;9(2):e83871.
5.
Figure 4

Figure 4. ERG responses in 16 week old GHL+ and GHL+/Chop−/− mice.. From: Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa.

(A) Average scotopic ERG a- and b-wave waveforms from C57BL/6 (blue traces), Chop−/− (orange traces) GHL+ (black traces) and GHL+/Chop−/− (red traces) mice in response to 1 ms flashes of increasing intensity, from bottom to top, (n = 8–13). (B) Intensity-response functions of a- and b-waves. Error bars ± SD. Scale bar: x = 50 ms, y = 200 µV. Arrows represent the onset of light stimulus.

Adeseye Adekeye, et al. PLoS One. 2014;9(2):e83871.
6.
Figure 2

Figure 2. ERG responses in 4 week old GHL+ and GHL+/Chop−/− mice.. From: Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa.

(A) Average scotopic ERG a- and b-wave waveforms from C57BL/6 (blue traces), Chop−/− (orange traces) GHL+ (black traces) and GHL+/Chop−/− (red traces) mice in response to 1 ms flashes of increasing intensity, from bottom to top, (n = 7–9). (B) Intensity-response functions of a- and b-waves. Error bars: ± SD. Scale bar: x = 50 ms, y = 200 µV. Arrows represent the onset of light stimulus.

Adeseye Adekeye, et al. PLoS One. 2014;9(2):e83871.
7.
Figure 3

Figure 3. Histological analysis of 4 week old GHL+ and GHL+/Chop−/− retinas.. From: Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa.

(A) Representative sections of retinas from 4 week old C57BL/6, Chop−/−, GHL+ and GHL+/Chop−/− mice (n = 2–3). (B) Mean number of photoreceptor nuclei per column counted in the ONL (left panel), and the variance in the number of photoreceptor nuclei per column counted in different zones of the retina in GHL+ and GHL+/Chop−/− mice, (right panel). Superior zone: 630 µm from the CMZ, central zone: 630 µm from optic nerve, and inferior zone: midpoint of inferior hemisphere. Error bars: ± SD OPL: outer plexiform layer, ONL: outer nuclear layer, OS: outer segment. Scale bar, 50 µm.

Adeseye Adekeye, et al. PLoS One. 2014;9(2):e83871.
8.
Figure 1

Figure 1. Effect of Chop on the expression of phototransduction genes and visual function.. From: Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa.

(A). Quantitative RT-PCR analysis of 4 week old C57BL/6 and Chop−/− mice (n = 4). Samples were normalized to β-actin levels. (B). Average scotopic ERG a- and b-wave waveforms from 4 week old C57BL/6 (blue trace) and Chop−/− (orange trace) mice in response to 1 ms flashes (n = 7–9). (C) Intensity-response functions of a- and b-waves recorded from the same C57BL/6 and Chop−/− mice. Horizontal lines and vertical intercepts on the abscissa (a-wave It: 50 µV, b-wave It: 75 µV) show the method used to determine threshold light intensities (It). (D) Age related changes in a- and b-wave threshold light intensities in C57BL/6 and Chop−/− mice. Error bars are ± SD.

Adeseye Adekeye, et al. PLoS One. 2014;9(2):e83871.
9.
Figure 5

Figure 5. Histological analysis of 16 and 28 week old GHL+ and GHL+/Chop−/− mice.. From: Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa.

(A) Representative sections of retinas from 16 week old C57BL/6, Chop−/−, GHL+ and GHL+/Chop−/− mice. GHL+ and GHL+/Chop−/− retinas had shortened OS (arrowheads). (B, right panel) Mean number of photoreceptor nuclei per column counted in the ONL at 16 weeks. The variance in the number of photoreceptor nuclei per column counted in different zones of the retina in (B, left panel) in 16 week. (C) Representative sections of retinas from 28 week old GHL+ and GHL+/Chop−/− mice. (D) The variance in the number of photoreceptor nuclei per column counted in different zones of the retina in 28 week old GHL+ and GHL+/Chop−/− mice. Superior zone: 630 µm from the CMZ, central zone: 630 µm from optic nerve, and inferior zone: midpoint of inferior hemisphere. Error bars: ± SD OPL: outer plexiform layer, ONL: outer nuclear layer, OS: outer segment. Scale bar 50 µm.

Adeseye Adekeye, et al. PLoS One. 2014;9(2):e83871.
10.
Figure 10

Figure 10. Age related changes in retinal function and morphology of GHL+ and GHL+/Ask1−/− mice.. From: Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa.

(A) b/a wave ratio in C57BL/6, Ask1−/−, GHL+, and GHL+/Ask1−/− mice. (B) Representative sections of retinas from 16 week old C57BL/6, Ask1−/−, GHL+ and GHL+/Ask1−/− mice. GHL+ and GHL+/Ask1−/− retinas had shortened OS (arrowheads). (C) Mean number of photoreceptor nuclei per column counted in the ONL. Error bars: ± SD. OPL: outer plexiform layer, ONL: outer nuclear layer, OS: outer segment. Scale bar 50 µm. (D) The variance in the number of photoreceptor nuclei per column counted in different zones of the retina in GHL+ and GHL+/Ask1−/− mice, (right panel). Superior zone: 630 µm from the CMZ, central zone: 630 µm from optic nerve, and inferior zone: midpoint of inferior hemisphere.

Adeseye Adekeye, et al. PLoS One. 2014;9(2):e83871.

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