We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 4

1.
Scheme 1

Scheme 1. From: Synthesis of piperlogs and analysis of their effects on cells.

Synthetic procedures for the preparation of piperlogs.

Zarko V. Boskovic, et al. Tetrahedron. ;69(36):10.1016/j.tet.2013.05.080.
2.
Figure 2

Figure 2. From: Synthesis of piperlogs and analysis of their effects on cells.

EC50 values of tethered ‘dimeric’ imide-containing piperlogs in H1703 and HeLa cell lines. All data are expressed as mean ± standard deviation for three independent experiments.

Zarko V. Boskovic, et al. Tetrahedron. ;69(36):10.1016/j.tet.2013.05.080.
3.
Figure 3

Figure 3. From: Synthesis of piperlogs and analysis of their effects on cells.

Viability (top left) and ROS increase (top right) of ‘dimeric’ piperlogs with C7-C8 olefin modifications determined from three independent experiments. All data are expressed as mean ± standard deviation for three independent experiments.

Zarko V. Boskovic, et al. Tetrahedron. ;69(36):10.1016/j.tet.2013.05.080.
4.
Figure 1

Figure 1. From: Synthesis of piperlogs and analysis of their effects on cells.

a) Previously established SAR of piperlongumine, PL, with carbon numbering used in this paper; b) EC50 of PL in H1703 and HeLa cells determined from three independent assays; c) Structures of dihydronaphthalene PL analog, PL-DHN; C7-C8 dihydro PL, PL-H2; and tethered PL ‘dimer’, PL-DI.

Zarko V. Boskovic, et al. Tetrahedron. ;69(36):10.1016/j.tet.2013.05.080.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk