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1.
Figure 2

Figure 2. From: Adventitial Nab-Rapamycin Injection Reduces Porcine Femoral Artery Luminal Stenosis Induced by Balloon Angioplasty via Inhibition of Medial Proliferation and Adventitial Inflammation.

Femoral artery endothelialization after balloon angioplasty injury (bar is median, 2 pigs per treatment per time point).

Warren J. Gasper, et al. Circ Cardiovasc Interv. ;6(6):701-709.
2.
Figure 5

Figure 5. From: Adventitial Nab-Rapamycin Injection Reduces Porcine Femoral Artery Luminal Stenosis Induced by Balloon Angioplasty via Inhibition of Medial Proliferation and Adventitial Inflammation.

Time course of medial cell proliferation (Ki-67 index) in control (2 pigs per time point) and nab-rapamycin-treated (2 pigs per time point) femoral arteries.

Warren J. Gasper, et al. Circ Cardiovasc Interv. ;6(6):701-709.
3.
Figure 4

Figure 4. From: Adventitial Nab-Rapamycin Injection Reduces Porcine Femoral Artery Luminal Stenosis Induced by Balloon Angioplasty via Inhibition of Medial Proliferation and Adventitial Inflammation.

Time course of adventitial leukocyte infiltration in control (2 pigs per time point) and nab-rapamycin-treated (2 pigs per time point) femoral arteries. HPF indicates high-power field.

Warren J. Gasper, et al. Circ Cardiovasc Interv. ;6(6):701-709.
4.
Figure 6

Figure 6. From: Adventitial Nab-Rapamycin Injection Reduces Porcine Femoral Artery Luminal Stenosis Induced by Balloon Angioplasty via Inhibition of Medial Proliferation and Adventitial Inflammation.

Rapamycin concentrations in blood and femoral artery/perivascular tissues after a femoral artery injury and adventitial injection of nab-rapamycin (2 pigs per time point). ND indicates not detectable.

Warren J. Gasper, et al. Circ Cardiovasc Interv. ;6(6):701-709.
5.
Figure 1

Figure 1. From: Adventitial Nab-Rapamycin Injection Reduces Porcine Femoral Artery Luminal Stenosis Induced by Balloon Angioplasty via Inhibition of Medial Proliferation and Adventitial Inflammation.

Photographs and illustrations of the Bullfrog Micro-Infusion Catheter (A). Sequential angiogram images during microinfusion catheter deployment and adventitial injection in a pig femoral artery (B). Five-point grading scale for adventitial injection coverage and location (C). Images courtesy of Mercator MedSystems.

Warren J. Gasper, et al. Circ Cardiovasc Interv. ;6(6):701-709.
6.
Figure 3

Figure 3. From: Adventitial Nab-Rapamycin Injection Reduces Porcine Femoral Artery Luminal Stenosis Induced by Balloon Angioplasty via Inhibition of Medial Proliferation and Adventitial Inflammation.

Representative histology images of pig femoral arteries 28 days after balloon angioplasty injury and adventitial injection in control (left) or nab-rapamycin (right) groups. Control arteries (A) had increased neointimal hyperplasia and luminal stenosis on hematoxylin and eosin staining compared with nab-rapamycin–treated arteries (B). Low- and high-power views of Masson trichrome stained control (C and E) and nab-rapamycin–treated arteries (D and F) demonstrate increased medial fibrosis (blue staining) in control arteries. Control arteries demonstrated more medial cell proliferation (Ki-67–stained cells in brown; G) than nab-rapamycin–treated arteries (H). Control arteries (I) had significantly more adventitial microvessels (arrow, Factor VIII staining) than nab-rapamycin–treated arteries (J). There was no significant difference endothelialization between control (K) and nab-rapamycin–treated (L) arteries (Factor VIII staining). *Marks media. Bar, 1 mm in AD. Bar, 100 μm in EL.

Warren J. Gasper, et al. Circ Cardiovasc Interv. ;6(6):701-709.

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