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Results: 15

1.
Figure 8

Figure 8. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

Drug release profiles of DTZ-loaded MLMDTs in pH 1.2.

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
2.
Figure 12

Figure 12. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

Typical force-displacement profiles for (a) THP-loaded MLMDTs in pH 1.2 and 6.8 and (b) DTZ-loaded MLMDTs in pH 1.2.

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
3.
Figure 9

Figure 9. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

Correlation of swelling and erosion profiles of (a) THP-loaded and (b) DTZ-loaded MLMDTs.

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
4.
Figure 6

Figure 6. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

Drug release profiles of optimized (a) THP and (b) DTZ-loaded MLMDT formulations.

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
5.
Figure 14

Figure 14. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

SEM image illustrating morphology of the pectin/Avicel (PBL) and HPMC (HBL1) layers (magnification 355x).

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
6.
Figure 13

Figure 13. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

FTIR spectra depicting (a) pure THP and compressed THP MLMDT and (b) pure DTZ and compressed DTZ-loaded MLMDT.

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
7.
Figure 3

Figure 3. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

Schematic representing a Multilayer Perceptron (MLP) with two hidden layers.

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
8.
Figure 2

Figure 2. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

Schematic model depicting a representative ideal drug release profile from the MLMDT.

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
9.
Figure 4

Figure 4. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

A typical bar chart portraying the ANN-derived sensitivity of HEC, EC, and sodium bicarbonate on k 3.

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
10.
Figure 7

Figure 7. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

Drug release profiles of THP-loaded MLMDTs in pH 1.2 (2 hrs) and pH 6.8 (3 hours onwards).

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
11.
Figure 1

Figure 1. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

Schematic of the Multilayered Multidisk Tablet (MLMDT) consisting of two drug disks surrounded by barrier layers (PBL1, HBL1, and HBL2).

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
12.
Figure 5

Figure 5. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

(a) Profiles showing the effect of EC and HEC on k 3; (b) profile showing the influence of sodium bicarbonate on k 3.

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
13.
Figure 11

Figure 11. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

The MLMDT tablet showing the difference between the top and bottom layers of the device as based on the different polymers employed in the layers.

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
14.
Figure 10

Figure 10. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

Digital images depicting (a) swollen THP-loaded MLMDTs and (b) swollen DTZ-loaded MLMDTs at (A) 2, (B) 4, (C) 6, (D) 8, (E) 10, (F) 12, and (G) 24 hours, respectively.

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.
15.
Figure 15

Figure 15. From: A Novel Multilayered Multidisk Oral Tablet for Chronotherapeutic Drug Delivery.

Energy minimized geometrically constrained models of the following. (a) Ethylcellulose and hydroxyethylcellulose before complexation; (b) EC-HEC complex derived from MM computations. The atoms in close interaction proximity are emphasized by space filling model (dots) where the yellow dots depict atoms involved in H-bonding. Color codes for elements are carbon (cyan), nitrogen (blue), oxygen (red), and hydrogen (white). (c) Avicel (cellulose) and pectin before complexation; (d) PEC-AVC complex derived from MM computations. The atoms in close interaction proximity are emphasized by space filling model (dots) where the yellow dots depict atoms involved in H-bonding. Color codes for elements are carbon (cyan), nitrogen (blue), oxygen (red), and hydrogen (white).

Zaheeda Khan, et al. Biomed Res Int. 2013;2013:569470.

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