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1.
Figure 1

Figure 1. From: Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Representative bands for GABRα1, GABRα2, GABRα3, GABRα5, GABRα6, GABRβ1, GABRβ2, GABRβ3, GABRδ, GABRɛ, GABRγ2, GABRγ3, NSE and β-actin in the lateral cerebellum of subjects with schizophrenia and mood disorders.

S H Fatemi, et al. Transl Psychiatry. 2013 September;3(9):e303.
2.
Figure 5

Figure 5. From: Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Expression of GABRγ3/β-actin (a), GABRγ3/NSE (b), β-actin (c) and NSE (d) in the lateral cerebella of healthy control subjects versus subjects with bipolar disorder, major depressive disorder and schizophrenia. Histogram bars shown as mean±s.e., *P<0.05.

S H Fatemi, et al. Transl Psychiatry. 2013 September;3(9):e303.
3.
Figure 2

Figure 2. From: Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Expression of GABRα1/β-actin (a), GABRα1/NSE (b), GABRα2/β-actin (c), GABRα2/NSE (d), GABRα3/β-actin (e), GABRα3/NSE (f), GABRα5/β-actin (g) and GABRα5/NSE (h) in the lateral cerebella of healthy control subjects versus subjects with bipolar disorder, major depressive disorder and schizophrenia. Histogram bars shown as mean±s.e., *P<0.05.

S H Fatemi, et al. Transl Psychiatry. 2013 September;3(9):e303.
4.
Figure 4

Figure 4. From: Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Expression of GABRβ3 lower band/β-actin (a), GABRβ3 lower band/NSE (b), GABRδ/β-actin (c), GABRδ/NSE (d), GABRɛ/β-actin (e), GABRɛ/NSE (f), GABRγ2/β-actin (g) and GABRγ2/NSE (h) in the lateral cerebella of healthy control subjects versus subjects with bipolar disorder, major depressive disorder and schizophrenia. Histogram bars shown as mean±s.e., *P<0.05.

S H Fatemi, et al. Transl Psychiatry. 2013 September;3(9):e303.
5.
Figure 3

Figure 3. From: Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Expression of GABRα6/β-actin (a), GABRα6/NSE (b), GABRβ1/β-actin (c), GABRβ1/NSE (d), GABRβ2/β-actin (e), GABRβ2/NSE (f), GABRβ3 upper band/β-actin (g) and GABRβ3 upper band/NSE (h) in the lateral cerebella of healthy control subjects versus subjects with bipolar disorder, major depressive disorder and schizophrenia. Histogram bars shown as mean±s.e., *P<0.05.

S H Fatemi, et al. Transl Psychiatry. 2013 September;3(9):e303.
6.
Figure 10

Figure 10. From: Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Altered mRNA expression of γ-aminobutyric acid A (GABAA) receptor subunits in various cells of the cerebellar circuitry of subjects with schizophrenia (S), bipolar disorder (B) or major depression (D). R2, GABAB receptor 2. GABAB receptor subunits 1 and 2 (GABBR1 and GABBR2) data reprinted from Fatemi et al.,29 with permission from Elsevier.

S H Fatemi, et al. Transl Psychiatry. 2013 September;3(9):e303.
7.
Figure 9

Figure 9. From: Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Altered protein expression of γ-aminobutyric acid A and B (GABAA and GABAB) receptor subunits in various cells of the cerebellar circuitry of subjects with schizophrenia (S), bipolar disorder (B) or major depression (D). R1, GABAB receptor 1; R2, GABAB receptor 2. GABAB receptor subunits 1 and 2 (GABBR1 and GABBR2) data reprinted from Fatemi et al.,29 with permission from Elsevier.

S H Fatemi, et al. Transl Psychiatry. 2013 September;3(9):e303.
8.
Figure 6

Figure 6. From: Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Summary of significant mRNA and protein expression for γ-aminobutyric acid A and B (GABAA and GABAB) receptors in the lateral cerebella of subjects with schizophrenia. Increased expression of GABRα2 protein may lead to a negative feedback loop decreasing the mRNA expression. ↑, increased expression; ↓, reduced expression, --, no change. GABAB receptor subunits 1 and 2 (GABBR1 and GABBR2) data reprinted from Fatemi et al.,29 with permission from Elsevier.

S H Fatemi, et al. Transl Psychiatry. 2013 September;3(9):e303.
9.
Figure 8

Figure 8. From: Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Summary of significant mRNA and protein expression for γ-aminobutyric acid A and B (GABAA and GABAB) receptors in the lateral cerebella of subjects with major depression. Increased expression of GABRα1 protein may lead to a negative feedback loop decreasing the mRNA expression. ↑, increased expression; ↓, reduced expression, --, no change. GABAB receptor subunits 1 and 2 (GABBR1 and GABBR2) data reprinted from Fatemi et al.,29 with permission from Elsevier.

S H Fatemi, et al. Transl Psychiatry. 2013 September;3(9):e303.
10.
Figure 7

Figure 7. From: Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder.

Summary of significant mRNA and protein expression for γ-aminobutyric acid A and B (GABAA and GABAB) receptors in the lateral cerebella of subjects with bipolar disorder. Decreased expression of GABAB receptor subunit 2 (GABRR2) protein may lead to a positive feedback loop increasing the mRNA expression. ↑, increased expression; ↓, reduced expression, --, no change. GABAB receptor subunit 1 (GABBR1) and GABBR2 data reprinted from Fatemi et al.,29 with permission from Elsevier.

S H Fatemi, et al. Transl Psychiatry. 2013 September;3(9):e303.

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