Results: 3

1.

Figure. From: Toward a comprehensive and systematic methylome signature in colorectal cancers.

Figure 3. Pyrosequencing validation of Illumina HumanMethylation27 array data. Pyrosequencing results of CpG islands that include the CpG site that was analyzed by the Illumina array for each gene. (A) Validation results of Illumina hypermethylated genes. (B) Validation results of Illumina hypomethylated genes. Error bars represent STD of methylation (%) between CpG sites within the CpG islands analyzed. No statistical differences were found.

Hassan Ashktorab, et al. Epigenetics. 2013 August 1;8(8):807-815.
2.

Figure. From: Toward a comprehensive and systematic methylome signature in colorectal cancers.

Figure 2. Schematic representation of approaches used to identify appropriate genes for validation of CpG island methylation resulting from Illumina HumanMethylation27 Array data. The Illumina HumanMethylation27 Array analyzes 27,579 individual CpG sites and bioinformatics approaches are used to sort the data. The left side of the flowchart highlights our first approach at selecting genes for validation, which was unsuccessful. The right side of the flowchart highlights our second approach at selecting genes for validation, which is currently being attempted in the lab.

Hassan Ashktorab, et al. Epigenetics. 2013 August 1;8(8):807-815.
3.

Figure. From: Toward a comprehensive and systematic methylome signature in colorectal cancers.

Figure 1. Cluster profile analysis of colonic samples. Using the IHM27, we generated the methylation profiles of 12 cancers, 8 adenomas and 2 normal colonic tissues. A clustering of the different samples based on their methylome profiles led to a clear resolution between the cancer samples and the adenomas. The normal tissue clustered with the adenomas. With the exception of one adenoma (tubuvillus type) all the cancer samples was clustered together.

Hassan Ashktorab, et al. Epigenetics. 2013 August 1;8(8):807-815.

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