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1.
Figure 3

Figure 3. From: Changes in the Cochlear Vasculature and Vascular Endothelial Growth Factor and Its Receptors in the Aging C57 Mouse Cochlea.

There was no basal to apex difference in VEGF labelling intensity in old C57 mice.

David Clinkard, et al. ISRN Otolaryngol. 2013;2013:430625.
2.
Figure 2

Figure 2. From: Changes in the Cochlear Vasculature and Vascular Endothelial Growth Factor and Its Receptors in the Aging C57 Mouse Cochlea.

There was a significant upregulation in Flt-1 in older animals (2.16-fold versus 1.36-fold, P < 0.05). No difference was seen in VEGF-A or Flk-1 expression.

David Clinkard, et al. ISRN Otolaryngol. 2013;2013:430625.
3.
Figure 1

Figure 1. From: Changes in the Cochlear Vasculature and Vascular Endothelial Growth Factor and Its Receptors in the Aging C57 Mouse Cochlea.

ABR demonstrated significant attenuation of response at all pure tone frequencies confirming elevated thresholds in old C57 mice.

David Clinkard, et al. ISRN Otolaryngol. 2013;2013:430625.
4.
Figure 6

Figure 6. From: Changes in the Cochlear Vasculature and Vascular Endothelial Growth Factor and Its Receptors in the Aging C57 Mouse Cochlea.

Vessel area displayed a trend toward decreased luminal area (17.5 μm2 versus 21 μm2, P = 0.052) in old C57 mice. There was no difference in vessel area due to age in SW animals (young 40.93 μm2, old 43.85 μm2). C57 animals had a significantly reduced area compared to SW.

David Clinkard, et al. ISRN Otolaryngol. 2013;2013:430625.
5.
Figure 4

Figure 4. From: Changes in the Cochlear Vasculature and Vascular Endothelial Growth Factor and Its Receptors in the Aging C57 Mouse Cochlea.

(a) Old C57BL mice display marked decreases in vessel number and size. Old C57 striae appear significantly more disorganized than young C57 animals. (b) Vascularity decreased significantly with age in C57 animals (4.9% ± 0.02% versus 3.9% ± 0.02%,  P < 0.05). There was no difference in vascularity with age in young versus old SW animals (9.7% ± 0.02% versus 10.5% ± 0.02%).

David Clinkard, et al. ISRN Otolaryngol. 2013;2013:430625.
6.
Figure 5

Figure 5. From: Changes in the Cochlear Vasculature and Vascular Endothelial Growth Factor and Its Receptors in the Aging C57 Mouse Cochlea.

There was a significant decrease in vessel number (7.4 versus 9.56, P < 0.05) in aged C57 mice compared to young animals. There was no significant difference due to age (young 5.5, old 6.4) in vessel number in the SW animals. SW animals had a significantly reduced number of vessels compared to C57 at all ages (P < 0.05).

David Clinkard, et al. ISRN Otolaryngol. 2013;2013:430625.

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