Results: 2

1.
Figure 1

Figure 1. From: Genetic Evidence for Recent Population Mixture in India.

Principal Component Analysis
(A) Map showing the sampling locations for Indian groups in our study (except central_mix1_nihali 7 ).
(B) Principal component analysis (PCA) of 70 of 73 groups with non-Indians (European Americans [CEU], Georgian, Iranian, Basque, and Han Chinese [CHB]) highlights the “Indian cline,” a gradient of West Eurasian relatedness. Great Andamanese and Siddi are not included because of their evidence of relatively recent admixture with non-Indian groups, and central_mix1_nihali 7 is not included because it includes multiple ethno-linguistic groups under one label. To aid visualization, we represent each group by the average PCA coordinates of all the individuals in it. Footnote a indicates groups from Metspalu et al. 7 and footnote b indicates groups from HGDP.

Priya Moorjani, et al. Am J Hum Genet. 2013 September 5;93(3):422-438.
2.
Figure 2

Figure 2. From: Genetic Evidence for Recent Population Mixture in India.

Dates of Mixture
We pool samples based on linguistic affiliation (Indo-Europeans [n = 175] and Dravidians [n = 144]) and run rolloff (with the merged Illumina-Affymetrix data set of 86,213 SNPs) to measure the LD resulting from mixture between ANI and ASI. To obtain weights proportional to the allele frequency differences between ANI and ASI at each SNP (needed to run rolloff), we use SNP loadings obtained from a PCA of Basque and a pool of groups from the linguistic cluster whose admixture is not being dated (e.g., we run PCA with Indo-European and Basque when we are dating Dravidian admixture). The output of rolloff is represented as points and the line shows the exponential fit used for estimating the time in generations (n) since mixture. The nonzero constant c allows for variability in the mixture proportion among the groups we pooled and d is the genetic distance in Morgans. Standard errors are computed via a weighted block jackknife (see Material and Methods).

Priya Moorjani, et al. Am J Hum Genet. 2013 September 5;93(3):422-438.

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