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Figure 1

Figure 1. From: Association of myeloperoxidase with ovarian cancer.

MPO expression in epithelial ovarian cancer cells.
A. Digital confocal image (Delta Vision microscope) of stage 1 ovarian endometriod cancer shows MPO (Alexa Fluor 488, green) immunostaining in columnar ovarian epithelial cancer cells, and nearby CD68 positive (Alexa Fluor 594, red) monocyte-macrophages lacking MPO co-staining.
B. Digital confocal image of another region of the same tumor showing MPO (Alexa Fluor 488, green) positive epithelial cancer cells in the absence of nearby CD68 positive macrophages (Alexa Fluor 594, red).
C. Digital confocal image from the same tumor showing colocalization (yellow) of MPO (Alexa Fluor 488, green) and CD68 (red) in macrophages invading an epithelial structure.
D. Control image of a nearby section of the same ovarian cancer section seen in panel A showing lack of fluorescent staining with the Alexa Fluor 488 anti-rabbit IgG in the absence of the primary antibody.
E. Control image of a nearby section stained with an irrelevant rabbit IgG antibody and the Alexa Fluor 488 anti-rabbit IgG.
F. Control image of a section near that seen in panel C stained with an irrelevant mouse IgG control antibody and Alexa Fluor 594 anti-mouse IgG.
G. MPO immunoperoxidase staining in a papillary region of a borderline tumor.
H. Boxed area in panel D is shown at higher magnification showing MPO immunostaining in a complex cellular structure.
I. High levels of MPO immunostaining (red arrow) in a stage 3 serous tumor in both tumor cells and infiltrating neutrophils and monocyte-macrophages.

Dan Cacsire Castillo-Tong, et al. Tumour Biol. ;35(1):141-148.

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