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Results: 3

1.
Figure 3.

Figure 3. From: DNA Hypomethylation, Ambient Particulate Matter, and Increased Blood Pressure: Findings From Controlled Human Exposure Experiments.

Associations of Alu and TLR4 methylation with systolic and diastolic blood pressure (BP). Standardized βs and 95% confidence intervals are shown in the figure. Standardize βs express the changes in BP as fractions of the BP standard deviation associated with a decrease in DNA methylation equal to its standard deviation. TLR4 indicates toll‐like receptor‐4.

Andrea Bellavia, et al. J Am Heart Assoc. 2013 June;2(3):e000212.
2.
Figure 2.

Figure 2. From: DNA Hypomethylation, Ambient Particulate Matter, and Increased Blood Pressure: Findings From Controlled Human Exposure Experiments.

Effect of controlled exposures to fine concentrated ambient particles (CAPs) and coarse CAPs on systolic and diastolic blood pressure (BP). Differences in CAPs vs medical air (control) exposures of systolic and diastolic BP in postexposure measurements. βs and 95% confidence intervals expressing the difference in BP (mm Hg) between CAPs exposures and control exposure (HEPA‐filtered medical air) in postexposures measurements. HEPA indicates high‐efficiency particulate air.

Andrea Bellavia, et al. J Am Heart Assoc. 2013 June;2(3):e000212.
3.
Figure 1.

Figure 1. From: DNA Hypomethylation, Ambient Particulate Matter, and Increased Blood Pressure: Findings From Controlled Human Exposure Experiments.

Effect of controlled exposures to fine CAPs (A) and coarse CAPs (B) on blood DNA methylation. Differences in CAPs vs medical air (control) exposures of DNA methylation in postexposure samples reported as standardized βs and 95% confidence intervals. βs indicate the differences between CAPs exposure and control exposure (HEPA‐filtered medical air) in the postexposure blood samples. βs are standardized to express the effect of CAPs exposure on DNA methylation as a fraction of the standard deviation of DNA methylation. Nominal P values (P), as well as P values adjusted for multiple testing (adjusted P) are shown for the significant effects. CAP indicates concentrated ambient particle; HEPA, high‐efficiency particulate air; LINE‐1, long interspersed nuclear element‐1; TLR4, toll‐like receptor‐4; IL‐6, interleukin 6; IL‐12, interleukin 12; iNOS, inducible nitric oxide synthase gene.

Andrea Bellavia, et al. J Am Heart Assoc. 2013 June;2(3):e000212.

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