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Figure 1

Figure 1. MS genetic burden scores in the 1000 Genomes Project population. From: Genetic risk variants in African Americans with multiple sclerosis.

Based on the 8 non-MHC MS SNPs for which the association with MS were replicated in African Americans (p < 0.01), aggregation of those SNPs was computed for individuals in the 1000 Genomes Project dataset, as previously described.40 Luhya in Webuye, Kenya, and Yoruba in Ibadan, Nigeria, are combined as “African”; Han Chinese in Beijing, China, Han Chinese South, and Japanese in Tokyo, Japan, are combined as “Asian”; Colombian in Medellin, Colombia, Mexican Ancestry in Los Angeles, CA, and Puerto Rican in Puerto Rico are combined as “Hispanic”; and Toscani in Italy, Iberian populations in Spain, Finnish from Finland, British from England and Scotland, and Northern and Western Europeans from Utah are combined as “European.” Additionally, genetic burden scores of our case-control dataset in AA and WA are included. A worldwide gradient of genetic burden scores was seen, matching MS prevalence in the world. Patients were more loaded than controls in both AA and WA. The p values at the top of the figure indicate the statistical significance of comparisons in groups next to each other (Wilcoxon rank sum test). The p value at the middle, bottom was calculated by Kruskal-Wallis test. Uncorrected p values are shown. AA = African Americans; ASW = African ancestry from southwest United States; K-W = Kruskal-Wallis test; MHC = major histocompatibility complex; MS = multiple sclerosis; SNP = single nucleotide polymorphism; WA = white Americans.

Noriko Isobe, et al. Neurology. 2013 July 16;81(3):219-227.

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