Results: 2

1.
Fig 1

Fig 1. From: Role of the LytSR Two-Component Regulatory System in Adaptation to Cationic Antimicrobial Peptides in Staphylococcus aureus.

Effect of lytSR and lrgAB on expression of the mprF and dlt genes. RNA samples were isolated from mid-exponential-growth-phase cultures of the strain set, and were subjected to qRT-PCR to detect and quantify transcription of mprF (A), dltA (B), and lrgA (C). The mid-exponential time point has been determined based on our pilot studies showing that expression of mprF and dlt is maximal at this time point. Comp, complemented strain.

Soo-Jin Yang, et al. Antimicrob Agents Chemother. 2013 August;57(8):3875-3882.
2.
Fig 2

Fig 2. From: Role of the LytSR Two-Component Regulatory System in Adaptation to Cationic Antimicrobial Peptides in Staphylococcus aureus.

In vitro HDP/CAP susceptibility assays following CCCP exposure. The strains tested were the S. aureus UAMS-1 parent, the ΔlytS mutant, the ΔlytS mutant containing the lytSR complementation plasmid (ΔlytS Comp), the ΔlrgAB mutant, and the ΔlrgAB mutant containing the lrgAB complementation plasmid (ΔlrgAB Comp). Cells were grown to mid-exponential phase (2.75 h) and then treated with CCCP (10 μM) for 15 min. The CCCP-treated cells were then assessed for hNP-1 (A) and DAP (B) susceptibility profiles compared to CCCP-unexposed cells. White bars, CCCP-free cultures; gray bars, CCCP-treated cultures. *, P < 0.01; **, P < 0.05.

Soo-Jin Yang, et al. Antimicrob Agents Chemother. 2013 August;57(8):3875-3882.

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