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1.
Fig. 3

Fig. 3. From: Adaptive optics optical coherence tomography for in vivo mouse retinal imaging.

(a) Schematic of the fundus lens positioned at the mouse cornea. (b) OCT image of a fundus lens near the cornea. (c) OCT image of a fundus lens in contact with the cornea.

Yifan Jian, et al. J Biomed Opt. 2013 May;18(5):056007.
2.
Fig. 5

Fig. 5. From: Adaptive optics optical coherence tomography for in vivo mouse retinal imaging.

A comparison of regular rodent OCT B-scan with high resolution AO-OCT B-scan (inside yellow dotted box acquired with AO-ON). Both images were acquired from C57BL/6J (pigmented) mouse, and were generated by averaging 20 motion-corrected B-scans. A logarithmic intensity scale was used for both sets of data. Note the smaller speckle size seen on AO FD-OCT inset. Scale bar: 100 μm.

Yifan Jian, et al. J Biomed Opt. 2013 May;18(5):056007.
3.
Fig. 4

Fig. 4. From: Adaptive optics optical coherence tomography for in vivo mouse retinal imaging.

Images from the WFS camera and corresponding log scale B-scans acquired simultaneously at the same location. A single WFS spot (in the red dotted circles) are shown at higher magnification in the heat maps, and the corresponding intensity profiles were taken at the position of the black line. (a) WFS image with nonoptimized focus. (b) WFS images acquired with the beam focus optimized on the outer retinal layers.

Yifan Jian, et al. J Biomed Opt. 2013 May;18(5):056007.
4.
Fig. 6

Fig. 6. From: Adaptive optics optical coherence tomography for in vivo mouse retinal imaging.

In vivo OCT B-scans images (left) acquired at the same eccentricity from the retinas of C57BL/6J (pigmented) mice and depth intensity profiles (right); (a) was acquired when AO is turned off (DM flat), (b) was acquired when AO was activated and the focus was set on the outer retina, and (c) was acquired when AO was activated and shifting the focus through the AO software to the inner retina. Images (a), (b), and (c) were generated by averaging 20 B-scans and are presented on a linear intensity scale. Scale bar: 50 μm.

Yifan Jian, et al. J Biomed Opt. 2013 May;18(5):056007.
5.
Fig. 7

Fig. 7. From: Adaptive optics optical coherence tomography for in vivo mouse retinal imaging.

Cross-sectional images of the mouse retina acquired in vivo with the AO FD-OCT system. The focal plane was set on the inner retina by changing the defocus in the AO control software. The axial depths indicated by the brackets in the B-scan represent the locations of (a) to (c) en face projections of different retinal layers with AO-ON and (d) to (f) en face projections at the same location with AO-OFF (DM flat). Scale bar: 30 μm.

Yifan Jian, et al. J Biomed Opt. 2013 May;18(5):056007.
6.
Fig. 2

Fig. 2. From: Adaptive optics optical coherence tomography for in vivo mouse retinal imaging.

(a) Measurement of the system residual aberrations with a paper phantom in the retinal plane. (b) A representative trace of the RMS wavefront error during mouse imaging. The corresponding Zernike coefficients measured (c) before and (d) during AO correction while imaging a mouse retina with the AO FD-OCT. Note that the scale of vertical axis in (a) is 10 times smaller than that of (c) and (d). (e) Averaged magnitude of Zernike coefficients and standard deviation before and after correction as measured for a sample of 8 mice. The Zernike coefficients follow the OSA standard for reporting the optical aberrations of eyes.

Yifan Jian, et al. J Biomed Opt. 2013 May;18(5):056007.
7.
Fig. 8

Fig. 8. From: Adaptive optics optical coherence tomography for in vivo mouse retinal imaging.

Cross-sectional and en face images (IPL, INL, OPL and PRL) of the mouse retina acquired in vivo with the AO FD-OCT system. The focal plane was adjusted on the layers of interest as indicated by the red brackets in the B-scan images by changing the defocus in the AO control software. The axial depths indicated by the brackets in the B-scan represent the locations of (a) to (d) en face projections of the different retinal layers with AO-ON and (e) (h) en face projections at the same location with AO-OFF (DM flat). Normalized line graphs of the image intensity taken across the capillaries at the locations labeled 1, 2, and 3 in (c) and (g) are presented in the bottom panel. Scale bar: 30 μm.

Yifan Jian, et al. J Biomed Opt. 2013 May;18(5):056007.
8.
Fig. 1

Fig. 1. From: Adaptive optics optical coherence tomography for in vivo mouse retinal imaging.

Schematic of the small animal AO FD-OCT system: DC–dispersion compensation; DM–deformable mirror; FC-20/80 fiber coupler, 20% of the light from SLD goes to sample arm, 80% goes to reference arm; GM1, GM2–horizontal and vertical galvo scanning mirrors; FL–fundus lens; PC–polarization controller; PBS–pellicle beam splitter; SLD–superluminescent diode; WFS–wavefront sensor; L–achromatic lenses: L0: (); L1, L2: (); L3, L4: (); L5, L6: (); L7, (); L8: (); OBJ – objective: (); ND–neutral density filter; represents the location of the planes conjugated to the pupil throughout the system; and represents the retinal conjugate planes. Inset: the mouse and fundus lens combination can be translated to adjust the focus. GM1 is a slow scan mirror and is presented unfolded for clarity. Note that the schematic is drawn for illustrative purposes only; it does not reflect the actual physical dimensions or the optical configuration of the system.

Yifan Jian, et al. J Biomed Opt. 2013 May;18(5):056007.

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