Fig. 1

Fig. 1. From: Relationship between White Matter Lesions and Progression of Cognitive Decline in Alzheimer's Disease.

Comparison of MMSE scores between baseline and follow-up in the WMLs(-), mild WMLs(+), and moderate WMLs(+) groups. Among AD patients without WMLs, MMSE scores improved in 14, declined in 11, and did not change in 2 patients. Among the 17 patients with mild WMLs, MMSE scores increased in 6 (35%), decreased in 9 (53%), and did not change in 2 patients (12%). Among the 12 patients with moderate WMLs, MMSE scores increased in 2 (17%), decreased in 7 (58%), and did not change in 3 patients (25%). The mean MMSE scores remained above baseline values during the approximately 1-year follow-up in the WMLs(-) group (from 20.2 ± 3.8 to 20.4 ± 5.5, p = 0.84), whereas they decreased in the mild WMLs(+) group from 17.9 ± 4.8 to 16.8 ± 6.5 (p = 0.29) as well as in the moderate WMLs(+) group from 18.3 ± 5.4 to 16.5 ± 4.4 (p = 0.09). ⚫ = Patients with increased MMSE scores; ⚪ = patients with decreased MMSE scores; ▲ = patients with stable MMSE scores.

Noriyuki Kimura, et al. Dement Geriatr Cogn Dis Extra. 2013 Jan-Dec;3(1):96-101.

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