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Results: 5

1.
Figure 2

Figure 2. Cognition after neonatal Met-Phen treatment.. From: Neonatal Disruption of Serine Racemase Causes Schizophrenia-Like Behavioral Abnormalities in Adulthood: Clinical Rescue by D-Serine.

Saline (1.0 ml/kg/day) or Met-Phen (3.0 mg/kg/day) was administered i.p. from P7 to P9. NORT was performed at juvenile (5–6 weeks old) and adult stages (10–12 weeks old). Data represent the mean ± S.E.M. (n = 8–11 mice for control group, n = 11 or 12 for Met-Phen group). *P<0.05, **P<0.01, *** P<0.001 compared with saline treated group.

Hiroko Hagiwara, et al. PLoS One. 2013;8(4):e62438.
2.
Figure 4

Figure 4. Effects of D-serine on PPI deficits at adult after neonatal Met-Phen treatment.. From: Neonatal Disruption of Serine Racemase Causes Schizophrenia-Like Behavioral Abnormalities in Adulthood: Clinical Rescue by D-Serine.

Met-Phen (3.0 mg/kg/day) was administered i.p. from P7 to P9. PPI test was performed at adult (10–12 weeks old). D-Serine (900 mg/kg, i.p.) or vehicle (saline; 10 ml/kg) was administered 30 minutes before PPI test. Data represent the mean ± S.E.M. (n = 7 mice for control group, n = 12 for D-serine group). *P<0.05, **P<0.01 compared with Met-Phen+vehicle treated group.

Hiroko Hagiwara, et al. PLoS One. 2013;8(4):e62438.
3.
Figure 1

Figure 1. Spontaneous locomotion after neonatal Met-Phen treatment.. From: Neonatal Disruption of Serine Racemase Causes Schizophrenia-Like Behavioral Abnormalities in Adulthood: Clinical Rescue by D-Serine.

Saline (1.0 ml/kg/day) or Met-Phen (3.0 mg/kg/day) was administered i.p. from P7 to P9. Horizontal activity and rearing activity were performed at juvenile (5–6 weeks old) and adult stages (10–12 weeks old). Data represent the mean ± S.E.M. (n = 9 mice for control group, n = 16 for Met-Phen group). ***P<0.001 compared with saline treated group.

Hiroko Hagiwara, et al. PLoS One. 2013;8(4):e62438.
4.
Figure 3

Figure 3. Auditory sensory gating PPI deficits after neonatal Met-Phen treatment.. From: Neonatal Disruption of Serine Racemase Causes Schizophrenia-Like Behavioral Abnormalities in Adulthood: Clinical Rescue by D-Serine.

Saline (1.0 ml/kg/day) or Met-Phen (3.0 mg/kg/day) was administered i.p. from P7 to P9. Auditory sensory gating PPI test was performed at juvenile (5–6 weeks old) and adult stages (10–12 weeks old). Data represent the mean ± S.E.M. (n = 11 mice for control group, n = 12 or 13 for Met-Phen group). *P<0.05 compared with saline treated group.

Hiroko Hagiwara, et al. PLoS One. 2013;8(4):e62438.
5.
Figure 5

Figure 5. Preventive effects of D-serine on PPI deficits at adult after neonatal Met-Phen treatment.. From: Neonatal Disruption of Serine Racemase Causes Schizophrenia-Like Behavioral Abnormalities in Adulthood: Clinical Rescue by D-Serine.

Met-Phen (3.0 mg/kg/day) was administered i.p. from P7 to P9. PPI test was performed at adult (11 weeks old). D-Serine (900 mg/kg/day, i.p.) or vehicle (saline; 10 ml/kg/day, i.p.) was administered chronically from P35 (5 weeks old) to P70 (10 weeks old). PPI test was performed 1 week (P77) after the final administration of D-serine. Data represent the mean ± S.E.M. (n = 5 mice for control group, n = 5 for D-serine group). *P<0.05, **P<0.01, ***P<0.001 compared with Met-Phen+vehicle treated group.

Hiroko Hagiwara, et al. PLoS One. 2013;8(4):e62438.

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