Results: 4

1.
Fig. 1.

Fig. 1. From: Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.

Blood-stage parasitemia during CPS immunization. Blood-stage parasitemia was measured from day 6 until day 10 after the first (I), second (II), and third (III) immunization by qPCR. Each line represents an individual subject (n = 15); values shown as 10 on the logarithmic scale were negative.

Else M. Bijker, et al. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7862-7867.
2.
Fig. 3.

Fig. 3. From: Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.

AEs and temperature after challenge. AEs and body temperature were recorded daily after challenge. Blood-stage challenge (A1) and sporozoite challenge (A2): mean number of possibly or probably related solicited AEs per subject. Blood-stage challenge (B1) and sporozoite challenge (B2): temperature (mean +SEM). Black line, group 1 (CPS-immunized, blood-stage challenge; n = 9); dashed dark gray line, group 3 (controls, blood-stage challenge; n = 5); light gray line, group 2 (CPS-immunized, sporozoite challenge; n = 5); dashed light gray line, group 4 (controls, sporozoite challenge; n = 5).

Else M. Bijker, et al. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7862-7867.
3.
Fig. 2.

Fig. 2. From: Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.

Parasitemia after challenge as assessed by qPCR. Geometric mean parasite density ±95% CI from day of inoculation until the day of treatment after blood-stage challenge [black line, group 1, CPS-immunized (n = 9); dashed dark gray line, group 3, controls (n = 5)] or sporozoite challenge [light gray line, group 2, CPS-immunized (n = 5); dashed light gray line, group 4, controls (n = 5)]. Values shown as 10 on the logarithmic scale were negative.

Else M. Bijker, et al. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7862-7867.
4.
Fig. 4.

Fig. 4. From: Protection against malaria after immunization by chloroquine prophylaxis and sporozoites is mediated by preerythrocytic immunity.

Hematological and inflammatory markers after challenge. (A) Peripheral lymphocyte counts (×109/L). (B) Platelet counts (difference from value at inclusion, ×109/L). (C) D-dimer (nanograms per milliliter). (D) IFN-γ (picograms per milliliter). (E) MIG (picograms per milliliter). Black line, group 1 (CPS-immunized, blood-stage challenge; n = 9); dashed dark gray line, group 3 (controls, blood-stage challenge; n = 5); light gray line, group 2 (CPS-immunized, sporozoite challenge; n = 5); dashed light gray line: Group 4 (controls, sporozoite challenge; n = 5). Data are shown as mean ± SEM.

Else M. Bijker, et al. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7862-7867.

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