Results: 2

1.
Figure 2

Figure 2. From: Molecular targeting of G? and G?? subunits: a potential approach for cancer therapeutics.

Structures of compounds that bind to Gα or Gβγ subunits.

Alan V. Smrcka. Trends Pharmacol Sci. ;34(5):290-298.
2.
Figure 1

Figure 1. From: Molecular targeting of G? and G?? subunits: a potential approach for cancer therapeutics.

Structural representations of Gαq and Gβγ with potential sites for small molecule interactions. (a) Gαq bound to YM-254890. The α helical domain is in blue, the Ras-like domain is in red and the linkers connecting the two domains are in green. GDP is in CPK and YM-254890 is in space fill yellow. Rendered from PDB 3AH8. (b) Surface representation of Gβ. In red is the contact surface for the SIGK peptide used in a completion screen for small molecule discovery. Rendered from PDB 1XHM using MolSoft ICM.

Alan V. Smrcka. Trends Pharmacol Sci. ;34(5):290-298.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk