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Figure 1

Figure 1. From: NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia.

Hypothesis of NMDAR hypofunction. (A) Schematic diagram of NMDAR complex. (B) NMDAR hypoactivity and glutamate neurotoxicity. PCP/MK801 ⇒ NMDAR hypofunction on GABAergic neurons ⇒ disinhibition of pyramidal neurons ⇒ more glutamate release ⇒ AMPA/KA receptors excessively stimulated ⇒ excitotoxic damage [Figure 1B was modified from (Olney et al., 1999)].

Melissa A. Snyder, et al. Front Cell Neurosci. 2013;7:31.

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