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Results: 5

1.
Figure 4

Figure 4. Relationships between the AD neurodegenerative biomarker and cognition. From: Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not beta-amyloid in cognitively normal older individuals.

Relationships between the multi-modality biomarker and memory performance (panel A.) as well as executive functions (panel B.) in the BAC NC sample. The scatter plots show that lower values of the multi-modality biomarker were related to lower memory and executive function. Unadjusted data are depicted; linear trends (dark solid line), 95% confidence intervals (light solid line) and individual data points (grey circles) are specified.

Miranka Wirth, et al. J Neurosci. ;33(13):5553-5563.
2.
Figure 1

Figure 1. Statistical surface maps. From: Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not beta-amyloid in cognitively normal older individuals.

Statistical surface maps (p < 0.00005) for FDG PET (A.), cortical thickness (cThick) (B.) and the FDG/cThick convergence (C.) as derived from the group contrast (ADNI NC > ADNI AD) in the derivation sample. For each surface map, significant clusters are color-coded. Yellow coloring illustrates cortical regions with the most significant AD-related hypometabolism and thinning. The red boundary indicates that the cluster size (cs) exceeded the minimum threshold of 300 mm2.

Miranka Wirth, et al. J Neurosci. ;33(13):5553-5563.
3.
Figure 2

Figure 2. Validation of the AD neurodegenerative biomarkers. From: Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not beta-amyloid in cognitively normal older individuals.

Distribution of the neurodegenerative biomarkers in the derivation (ADNI NC [blue], ADNI AD [orange]) and validation (BAC NC [black], UCSF AD [red]) samples. Error bar plots display group-means and standard deviation for each biomarker; the grey circles indicate individual data points. Panel A. The multi-modality biomarker was reduced for AD patients compared to normal controls (NC) across samples. The grey line denotes the discriminant cut-off score (values less than 0 indicate AD classification). Panels B – D. The single-modality biomarkers, i.e., cortical thickness (B.), FDG PET (C.), icv-adjusted hippocampal volume (HVicv, D.), showed prominent reductions for AD patients across samples.

Miranka Wirth, et al. J Neurosci. ;33(13):5553-5563.
4.
Figure 5

Figure 5. Interaction between the neurodegenerative biomarkers and high PIB uptake. From: Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not beta-amyloid in cognitively normal older individuals.

Relationships between the multi-modality biomarker and memory performance (panel A.) as well executive functions (panel B.) for the PIB uptake groups of the BAC NC sample. The scatter plots show that for the AD regions (upper panels) the association between the neurodegenerative biomarker and cognitive performance was significantly stronger for individuals with high PIB uptake (high PIB+ [solid black trend line]) compared to PIB negative (PIB-) subjects. For the control region, no significant interactions were observed (see text). Unadjusted data are depicted; linear trends (lines) and individual data points (circles) are specified.

Miranka Wirth, et al. J Neurosci. ;33(13):5553-5563.
5.
Figure 3

Figure 3. Relationships between the AD neurodegenerative biomarkers and PIB uptake. From: Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not beta-amyloid in cognitively normal older individuals.

Distribution of the neurodegenerative biomarkers in PIB negative (BAC NC PIB- [white]) and PIB positive (BAC NC PIB+ [solid black]) individuals. Panel A. The multi-modality biomarker values were comparable for PIB+ and PIB- individuals. The grey line denotes the discriminant cut-off score (values less than 0 indicate AD classification). Panels B – D. There were no significant differences in the single-modality biomarkers, i.e., cortical Thickness (B.), FDG PET (C.) and icv-adjusted hippocampal volume (HVicv, D.), between PIB+ and PIB- subjects. Error bar plots display group-means and standard deviation for each biomarker; the grey circles indicate individual data points.

Miranka Wirth, et al. J Neurosci. ;33(13):5553-5563.

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