We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 5

1.
Figure 2

Figure 2. Structurally linked functional connectivity.. From: Alterations in Prefrontal-Limbic Functional Activation and Connectivity in Chronic Stress-Induced Visceral Hyperalgesia.

Structural (SC) and functional connectivity (FC) networks are combined to create a structurally linked functional connectivity (SLFC) network such that final network contains all regions that the SC and FC networks have in common. Note the SLFC network inherits directionality information (denoted with arrows) from the SC network and the sign of functional interaction (positive/red or negative/blue correlation) from the FC network.

Zhuo Wang, et al. PLoS One. 2013;8(3):e59138.
2.
Figure 5

Figure 5. Stress-induced changes in the structurally linked functional connectivity (SLFC) of the prelimbic cortex (PrL) during colorectal distension (CRD).. From: Alterations in Prefrontal-Limbic Functional Activation and Connectivity in Chronic Stress-Induced Visceral Hyperalgesia.

The SLFC network contains both directionality information of the underlying structural connections (denoted with arrows) and the sign of functional interaction (positive/red or negative/blue statistically significant correlation).

Zhuo Wang, et al. PLoS One. 2013;8(3):e59138.
3.
Figure 1

Figure 1. Experimental design.. From: Alterations in Prefrontal-Limbic Functional Activation and Connectivity in Chronic Stress-Induced Visceral Hyperalgesia.

Visceral motor response (VMR) to colorectal distension (CRD) was measured before (day 0, baseline) and after (day 11) water avoidance stress (WAS) or sham treatment. Each time, CRDs of 10-, 20-, 40-, and 60-mmHg (duration = 20 s, interstimulus interval = 4 min) were delivered twice for each pressure level. On day 11, following VMR measurement, cerebral blood flow (CBF) mapping was performed while the animal was receiving a 60-mmHg CRD or no distension (0-mmHg control).

Zhuo Wang, et al. PLoS One. 2013;8(3):e59138.
4.
Figure 3

Figure 3. Effect of repeated water avoidance stress (WAS) on visceromotor response (VMR) to colorectal distension (CRD).. From: Alterations in Prefrontal-Limbic Functional Activation and Connectivity in Chronic Stress-Induced Visceral Hyperalgesia.

(A) VMR measured as electromyographic (EMG) area under the curve (AUC) and expressed as % of control (baseline VMR to 60-mmHg CRD) was significantly increased following WAS on day 11 compared to day 0 baseline (n = 20, F(1, 19) = 18.19, P<0.001, two-way repeated measures ANOVA). (B) Repeated sham procedure caused a moderate increase in VMR, primarily to 60-mmHg CRD (n = 18, F(1,17) = 4.67, P = 0.045, two-way repeated measures ANOVA). (C) Compared to sham-treated rats, stressed rats showed significantly greater increases in VMR after treatment (F(1,36) = 4.47, P = 0.042, mixed model ANOVA). Data are expressed as means ± SEM.

Zhuo Wang, et al. PLoS One. 2013;8(3):e59138.
5.
Figure 4

Figure 4. Comparison of colorectal distension (CRD)-induced functional brain activation in stressed and sham rats.. From: Alterations in Prefrontal-Limbic Functional Activation and Connectivity in Chronic Stress-Induced Visceral Hyperalgesia.

Statistically significant increases (red scale) and decreases (blue scale) in regional cerebral blood flow (rCBF) contrasting the subgroup receiving 60-mmHg CRD and the one receiving no distension (0-mmHg) are shown for the sham (left column) and water avoidance stress (WAS)-treated rats (middle column) over representative coronal slices of the brain template with anterior-posterior coordinates given relative to the bregma (n = 9 or 10/subgroup). Results of factorial analysis are also colorcoded showing regions with significant WAS x CRD interaction (right column). Abbreviations: aINS (anterior insular cortex), BL (basolateral amygdaloid n.), BM (basomedial amygdaloid n.), Cb (cerebellar lobule), Ce (central amygdaloid n.), Cg1/Cg2 (cingulate ctx. area 1/area 2), CPu (caudate putamen), fi (fimbria), Fr3 (frontal ctx. area 3), GP (globus pallidus), Hb (habenular n.), HPC (hippocampus), La (lateral amygdaloid n.), LD (laterodorsal thalamic n.), LPO (lateral preoptic area), M1 (primary motor ctx.), MD (mediodorsal thalamic n.), Me (medial amygdaloid n.), MPA (medial preoptic area), MPO (medial preoptic n., medial part), NAcc (n. accumbens), RS (retrosplenial ctx.), p1PAG(p1 periaqueductal gray), PF (parafascicular thalamic n.), pINS (posterior insular ctx.), PLH (peduncular part of lateral hypothalamus), Pir (piriform ctx.), Po (posterior thalamic n.), PrL (prelimbic ctx.), S1 (primary somatosensory ctx.), S2 (secondary somatosensory ctx.), SFi (septofimbrial n.), SO (superior olive), STIA (bed nucleus of the stria terminalis, intraamygdaloid division), STM (bed nucleus of the stria terminalis, medial division), V2 (secondary visual ctx.), VMH (ventromedial hypothalamic n.), VPL/VPM (ventral posteromedial/posterolateral thalamic n.). The left side of each coronal image represents the left side of the rodent brain.

Zhuo Wang, et al. PLoS One. 2013;8(3):e59138.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk