Figure. From: Gene loops and HDACs to promote transcription directionality.

Figure 1. Ssu72-dependent gene loops form upon ORF transcription, which results in reduced (Set3 dependent?) histone H4 acetylation at the promoter, restricting divergent pSRT transcription. pSRTs arise in ssu72–2 and are distinct from RRTs generated in the Rpd3s mutant Δrco1 at the 3′ end of genes in antisense orientation.

Manuele Castelnuovo, et al. Nucleus. 2013 March 1;4(2):92-94.

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