Results: 4

1.
Fig. 1.

Fig. 1. From: An algorithmic approach for breakage-fusion-bridge detection in tumor genomes.

Schematic BFB process.

Shay Zakov, et al. Proc Natl Acad Sci U S A. 2013 April 2;110(14):5546-5551.
2.
Fig. 3.

Fig. 3. From: An algorithmic approach for breakage-fusion-bridge detection in tumor genomes.

Algorithm for the BFB count-vector problem.

Shay Zakov, et al. Proc Natl Acad Sci U S A. 2013 April 2;110(14):5546-5551.
3.
Fig. 2.

Fig. 2. From: An algorithmic approach for breakage-fusion-bridge detection in tumor genomes.

Layer visualization of a BFB palindrome , where . A possible BFB sequence that produces α is . , and . (AD) Layers 1–4 of β, respectively. In each layer l, the l-blocks composing the collection Bl are annotated as substrings of the form βi.

Shay Zakov, et al. Proc Natl Acad Sci U S A. 2013 April 2;110(14):5546-5551.
4.
Fig. 4.

Fig. 4. From: An algorithmic approach for breakage-fusion-bridge detection in tumor genomes.

Simulation and pancreatic cancer results. (A) ROC curves for different count-vector lengths with and without fold-back fractions for the simulation of eight BFB rounds and equally likely other rearrangements. (B) Observed copy counts and copy counts compatible with BFB on the short arm of chromosome 12 in pancreatic cancer sample PD3641. The presence of fold-back inversions and the count vector’s consistency with BFB suggests that this portion of chromosome 12 underwent BFB cycles.

Shay Zakov, et al. Proc Natl Acad Sci U S A. 2013 April 2;110(14):5546-5551.

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