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FIGURE 1

FIGURE 1. Relationship Between Gating of Frequency Oscillations and the Paired-Click Paradigm and GABA Levels. From: GABA Predicts Inhibition of Frequency-Specific Oscillations in Schizophrenia.

[A]: Location of medial frontal spectroscopic voxel; [B]: GABA spectrum; [C]: Grand average of broadband (1–100 Hz) averaged evoked potentials from the 10 subjects, showing temporal windows in relationship to first stimulus (S1) and second stimulus (S2) that were used in single-trial analyses. T0: −100 to 25msec from the stimulus, T1: 26–150 msec, T2: 151–275 msec, and T3: 276–400 msec; [D]: Correlation of GABA level and gating of theta-alpha band at T1 (r = −0.68, p=0.03); E: Correlation of GABA level and gating of beta band at T1 (r = −0.85; p=0.002); [F]: Correlation coefficients (Y axis) of GABA level and gating across frequency bands (gamma, low gamma, beta, theta-alpha are shown here) and temporal windows (T0–T3). For example, gating of beta at T1 is the ratio of beta at T1 in response to S1 divided by beta at T1 in response to S2.
*Statistically significant.

Laura M. Rowland, et al. J Neuropsychiatry Clin Neurosci. 2013 Winter;25(1):83-87.

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