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Results: 4

1.
Fig 4

Fig 4. From: HIV-1 Conserved-Element Vaccines: Relationship between Sequence Conservation and Replicative Capacity.

Signature sites and replicative fitness. The relative fitness measured for 23 mutants of Gag-p24-COT-B is shown for signature sites (i.e., sites with a change in frequency between the 1980s and the 2000s) and nonsignature (nonsig.) sites. For the PBMC comparison, the P value in parentheses corresponds to all the data, including the zero value.

Morgane Rolland, et al. J Virol. 2013 May;87(10):5461-5467.
2.
Fig 3

Fig 3. From: HIV-1 Conserved-Element Vaccines: Relationship between Sequence Conservation and Replicative Capacity.

Sequence conservation over time and HLA-associated sites. The change in frequency between the consensus residue in the 1980s and 2000s is shown for all Gag-p24 sites (left panel) and for the 23 mutants of Gag-p24-COT-B assayed (right panel). Sites that have been previously identified as HLA associated and sites where no HLA association has been identified are compared.

Morgane Rolland, et al. J Virol. 2013 May;87(10):5461-5467.
3.
Fig 1

Fig 1. From: HIV-1 Conserved-Element Vaccines: Relationship between Sequence Conservation and Replicative Capacity.

Alignment of HIV-1 p24-COT (Center-of-Tree) sequences. Conserved elements (CE) used in initial vaccine studies (33) are in boldface. Mutated sites evaluated in fitness assays are boxed, and the frequency of the consensus subtype B residue is indicated. Sites shown in red were associated with a fitness cost and those in blue with a higher relative fitness. Sites shown in black showed no difference in relative fitness, and mutations at sites in gray were regarded as lethal as they yielded no productive infection.

Morgane Rolland, et al. J Virol. 2013 May;87(10):5461-5467.
4.
Fig 2

Fig 2. From: HIV-1 Conserved-Element Vaccines: Relationship between Sequence Conservation and Replicative Capacity.

Replicative fitness in PBMC and CEM cells as a function of HIV-1 subtype B sequence conservation (database [Db] amino acid [AA] frequency of the consensus residue). Mean relative fitness values are reported for mutants of Gag-p24-COT-B: 22 mutants in PBMC and 20 mutants in CEM cells. (Two mutant viruses that were noninfectious are not depicted.) The lines represent a least-squares fit to the data. Filled symbols correspond to mutations at signature sites: i.e., sites that showed a change in amino acid frequency between the 1980s and the 2000s.

Morgane Rolland, et al. J Virol. 2013 May;87(10):5461-5467.

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