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Results: 4

1.
Fig. 3

Fig. 3. From: Functional inhibition of UQCRB suppresses angiogenesis in zebrafish.

(A) Body curvature morphology was detected in 2 ng uqcrb-MO injected embryos at 24 and 48 hpf (n = 30, three independent trials). (B) Number of curved embryos increased dose-dependently in uqcrb-MO injected groups. (C) Survival rates decreased only down to 68.7% in 2 ng uqcrb-MO injected embryos. All quantified data are presented as mean ± SEM (*indicates p < 0.05). Scale bars indicate 200 μm.

Yoon Sun Cho, et al. Biochem Biophys Res Commun. ;433(4):396-400.
2.
Fig. 1

Fig. 1. From: Functional inhibition of UQCRB suppresses angiogenesis in zebrafish.

Knockdown of UQCRB inhibits zebrafish angiogenesis. (A) Complete ISVs at 30 hpf in control embryos. (B) Inhibition of angiogenesis in 1 ng uqcrb-MO injected embryos (n = 30, representative image from three independent trials). (C) Inhibition of angiogenesis in 2 ng uqcrb-MO injected embryos (n = 30, representative image from three independent trials). (D) Dose-dependent inhibition of angiogenesis in uqcrb-MO injected embryos. Quantified data are presented as mean ± SEM compared to control (**indicates p < 0.001, ***indicates p < 0.0001). Scale bar indicates 100 μm.

Yoon Sun Cho, et al. Biochem Biophys Res Commun. ;433(4):396-400.
3.
Fig. 2

Fig. 2. From: Functional inhibition of UQCRB suppresses angiogenesis in zebrafish.

(A) Angiogenic sprouts were detected starting from 24 hpf in control embryos. An average of 19.5 complete ISVs was detected in control embryos starting from 30 hpf. Complete ISVs were not detected in 1 and 2 ng uqcrb-MO injected embryos until 36 hpf. Only an average of three complete ISVs was examined in uqcrb-MO injected embryos (n = 5). (B) Angiogenic sprout length showed a great difference between control and dose-dependently decreased in uqcrb-MO injected embryos at all time frames. All quantified data are presented as mean ± SEM (*indicates p < 0.05, **indicates p < 0.001, ***indicates p < 0.0001).

Yoon Sun Cho, et al. Biochem Biophys Res Commun. ;433(4):396-400.
4.
Fig. 4

Fig. 4. From: Functional inhibition of UQCRB suppresses angiogenesis in zebrafish.

(A) UQCRB is conserved in human and zebrafish. The amino acid sequence alignment shows 72% similarity between human and zebrafish. (H: Homo sapiens, D: Danio rerio) Asterisks represent the identical amino acid of two sequences. (B) Terpestacin inhibited angiogenesis in zebrafish at 30 hpf. (C) The survival rate for terpestacin treated embryos decreased mildly to 80%. (D) Only an average of 0.5 complete ISV was examined in terpestacin treated embryos. The average number of angiogenic sprouts decreased to 15.2, compared to control embryos which had an average of 23 sprouts. (E) The length of angiogenic sprouts in terpestacin treated embryos decreased 47% compared to control. All quantified data are presented as mean ± SEM (***indicates p < 0.0001). (F) Vegfa levels decreased in uqcrb-MO injected embryos and terpestacin treated embryos at 30 hpf. Numbers indicate vegfa expression ratio compared to control (n = 35, three independent trials). Scale bar indicates 100 μm.

Yoon Sun Cho, et al. Biochem Biophys Res Commun. ;433(4):396-400.

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