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Results: 3

1.

Fig 2. From: 17-? Estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr−/− mice.

Post-treatment (10wk) aortic root atherosclerosis lesion area. A) Estrogen treatment significantly decreased the size of atherosclerotic lesions in the aortic root of both B6/LDLr−/− and Sle/LDLr−/− mice (n = 7–14 mice/group). B) Representative VVG sections of aortic roots (10x). Expansion of the intimal area is apparent in the placebo treated groups. Data expressed as mean ± SEM; * p < 0.0001.

KA Shelton, et al. Atherosclerosis. 2013 April;227(2):228-235.
2.

Fig 3. From: 17-? Estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr−/− mice.

Cholesterol distribution among serum lipoproteins and correlation with atherosclerosis lesion area. A) Placebo treated Sle/LDLr−/− mice had decreased serum VLDL-cholesterol (VLDL-C) and LDL-C concentration compared to placebo treated B6/LDLr−/− mice. Estrogen treatment decreased VLDL-C and LDL-C in B6/LDLr−/− mice, but not in Sle/LDLr−/− mice (p < 0.0007 for a vs. b within the respective lipoprotein category; n = 9–11 mice/group). There was no difference in HDL-C. After 10 weeks of treatment, there is a significant correlation between serum VLDL-C + LDL-C concentration with atherosclerosis lesion area in B6/LDLr−/− mice (B), but not in Sle/LDLr−/− mice (C). Data expressed as the mean ± SEM.

KA Shelton, et al. Atherosclerosis. 2013 April;227(2):228-235.
3.

Fig 1. From: 17-? Estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr−/− mice.

Study design and development of SLE disease. A) Six week old female mice were irradiated and received bone marrow transplants of either wild-type C57BL/6 or B6.Sle.1.2.3 bone marrow. Six weeks post-transplant (day zero) the mice were ovariectomized and randomized into estrogen (5.6 μg 17β-estradiol/day pellet) or placebo (5.6 μg placebo/day pellet) treatment groups and transferred to an atherogenic diet (0.001% cholesterol and 4.45% fat) for 10 weeks. B) Sle/LDLr−/− mice have increased renal disease compared to B6/LDLr−/− mice (n = 10–15 mice/group). Estrogen treatment did not affect the renal histopathology score when compared to placebo. C) Representative H&E sections of renal glomeruli (63X for all 4 frames). Glomeruli of the Sle/LDLr−/− mice are enlarged and hypercellular with thickened capillary basement membranes and hypertrophic Bowman’s epithelium. D) Serum anti-dsDNA antibody concentrations are increased in Sle/LDLr−/− mice compared to B6/LDLr−/− mice. Estrogen treatment did not alter anti-dsDNA antibody concentration when compared to placebo. E) Placebo treated Sle/LDLr−/− mice have an increased UP:UC ratio compared to placebo treated B6/LDLr−/− mice and estrogen treated Sle/LDLr−/− mice. F) Sle/LDLr−/− mice have splenomegaly when compared to B6/LDLr−/− mice (n = 10–15 mice/group). Estrogen treatment did not affect spleen weight when compared to placebo. G) Representative images of post-treatment spleens (mm). Data expressed as mean ± SEM; * p < 0.05.

KA Shelton, et al. Atherosclerosis. 2013 April;227(2):228-235.

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