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1.
Figure 1

Figure 1. α4β2 nAChR ligands. From: The Effects of Lobeline on ?4?2* Nicotinic Acetylcholine Receptor Binding and Uptake of [18F]Nifene in Rats.

Chemical structure of compounds with high affinity for the α4β2 nAChR site: (−)nicotine, lobeline, and [18F]nifene

Ansel T Hillmer, et al. J Neurosci Methods. 2013 April 15;214(2):163-169.
2.
Figure 2

Figure 2. Experimental designs. From: The Effects of Lobeline on ?4?2* Nicotinic Acetylcholine Receptor Binding and Uptake of [18F]Nifene in Rats.

A Protocol of Experiment 1, designed to examine the effects of lobeline on [18F]nifene binding and uptake. B Protocol of Experiment 2, which eliminated specific [18F]nifene binding with (−)nicotine to examine changes in [18F]nifene uptake rates due to lobeline.

Ansel T Hillmer, et al. J Neurosci Methods. 2013 April 15;214(2):163-169.
3.
Figure 3

Figure 3. Measured PET data from lobeline pre-blocking study, animal 1. From: The Effects of Lobeline on ?4?2* Nicotinic Acetylcholine Receptor Binding and Uptake of [18F]Nifene in Rats.

The time course of two [18F]nifene injections separated by displacement and blocking injections of lobeline is shown. No corrections have been applied for injected activity or the decay of radioactivity.

Ansel T Hillmer, et al. J Neurosci Methods. 2013 April 15;214(2):163-169.
4.
Figure 6

Figure 6. Simulations of [18F]nifene. From: The Effects of Lobeline on ?4?2* Nicotinic Acetylcholine Receptor Binding and Uptake of [18F]Nifene in Rats.

A The one-tissue compartment model. B Simulated PET signal with values of K1 and k2 individually changed while keeping a fixed ratio of K1/k2 = 4.5. C Simulated input functions with different shapes but a constant area. D The modeled PET signal resulting from the input functions in C.

Ansel T Hillmer, et al. J Neurosci Methods. 2013 April 15;214(2):163-169.
5.
Figure 4

Figure 4. Measured PET data from study with (−)nicotine blocking followed by lobeline, animal 1. From: The Effects of Lobeline on ?4?2* Nicotinic Acetylcholine Receptor Binding and Uptake of [18F]Nifene in Rats.

The time course of three [18F]nifene injections is shown. (−)Nicotine was administered after the first injection to eliminate specific binding. The second [18F]nifene injection yields information on uptake rates of nifene in the absence of specific binding. The third [18F]nifene injection measures changes to uptake rates due to the presence of lobeline. No corrections have been applied for injected activity or the decay of radioactivity.

Ansel T Hillmer, et al. J Neurosci Methods. 2013 April 15;214(2):163-169.
6.
Figure 5

Figure 5. Effects of lobeline on [18F]nifene uptake rates in the cerebellum. From: The Effects of Lobeline on ?4?2* Nicotinic Acetylcholine Receptor Binding and Uptake of [18F]Nifene in Rats.

A. An illustration of the extrapolation fitting procedure used to derive curves of nondisplaceable uptake CND1 and CND2. The data is from animal 1. No corrections have been applied for injected activity or the decay of radioactivity. B and C. A time-shifted overlay of the background subtracted time courses of [18F]nifene before (CND2, ) and after (CND3, ) the administration of lobeline for the two subjects (animals 1 and 2, respectively). These data (B and C) are scaled to the injected [18F]nifene dose for each injection. The injection times are shifted to provide a direct comparison of the data following [18F]nifene injections.

Ansel T Hillmer, et al. J Neurosci Methods. 2013 April 15;214(2):163-169.

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