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Results: 5

1.
Fig 5

Fig 5. From: Modeling the Acute and Chronic Phases of Theiler Murine Encephalomyelitis Virus Infection.

The rate constant (b) of infection of Mϕ by infectious debris via phagocytosis is strongly correlated with the rate constant (cID) of clearance of infectious debris.

Jingshan Zhang, et al. J Virol. 2013 April;87(7):4052-4059.
2.
Fig 3

Fig 3. From: Modeling the Acute and Chronic Phases of Theiler Murine Encephalomyelitis Virus Infection.

TMEV-specific antibody titers and modeling. Serum TMEV-specific antibody titers (dots; data are from reference 9) can be fitted using equation 7 (solid line). Antibody titers increased exponentially on day 5 p.i. and approached saturation (dashed line) by day 15 p.i.

Jingshan Zhang, et al. J Virol. 2013 April;87(7):4052-4059.
3.
Fig 4

Fig 4. From: Modeling the Acute and Chronic Phases of Theiler Murine Encephalomyelitis Virus Infection.

Parameter histograms from 6,000 sets of parameters which fit the data shown in Fig. 2 well using equation 10, as described in Materials and Methods. These histograms were used for the estimation of the range of unknown viral and host parameters (Table 1).

Jingshan Zhang, et al. J Virol. 2013 April;87(7):4052-4059.
4.
Fig 2

Fig 2. From: Modeling the Acute and Chronic Phases of Theiler Murine Encephalomyelitis Virus Infection.

TMEV kinetics and model simulation. Total TMEV RNA kinetic data (dots) can be patterns divided into 4 stages: (i) viral increase during the first 6 days p.i., (ii) viral decrease 6 to 11 days p.i., (iii) viral increase 11 to 13 days p.i., and (iv) steady state after approximately 15 day p.i. The viral RNA kinetic data were fitted by a mathematical model (equations 1 to 9) using a Monte Carlo filtering approach as described in Materials and Methods and Fig. 4. An example of good fit curve is shown by the solid line. Dots and bars represent means and one standard deviation of log10-transformed vRNA copy equivalents measured in spinal cords of infected mice (9).

Jingshan Zhang, et al. J Virol. 2013 April;87(7):4052-4059.
5.
Fig 1

Fig 1. From: Modeling the Acute and Chronic Phases of Theiler Murine Encephalomyelitis Virus Infection.

Schematic model of TMEV infection during the acute and chronic phases. The acute infection phase is plotted on the left (equations 1 to 3): uninfected motor neurons (T) are infected by free viruses (V) at rate βnV and become infected neurons (I). After 5 days p.i. virus-specific antibodies block infection with effectiveness η(t) (equations 7 and 8). Free virus is produced at rate constant pn and cleared at rate constant c. Motor neurons die only after they become infected at rate constant δn. The death of infected neurons generate infectious debris, ID. Within approximately 11 days p.i., TMEV-chemokine-recruited monocytes enter the CNS and differentiate into susceptible macrophages, Mϕ, at rate s(t) (equation 9). Uninfected Mϕ become infected, I, via phagocytosis of infectious debris, ID, at rate constant b. TMEV infection in Mϕ represents the transition from the acute to chronic phase and is plotted on the right (equations 4 to 6). Uninfected Mϕ, infected Mϕ, and infectious debris die or are lost at rate constants δ, δI, and cID, respectively. Loss and death rates are represented by dashed lines.

Jingshan Zhang, et al. J Virol. 2013 April;87(7):4052-4059.

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