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1.
Figure 2.

Figure 2. From: Optimizing the 6-Min Walk Test as a Measure of Exercise Capacity in COPD.

A, B, Scatterplots for change in walk distance vs change in exercise capacity measured on cardiopulmonary exercise testing in patients undergoing lung volume reduction surgery (n = 74). Each plot has a fitted regression line with 95% confidence bands. The scatter was closer to the line, the 95% confidence bands were narrower, and the correlation (r) was stronger for best-of-two walk distances compared with change in the first walk distance. The increase in the correlation was significant for the best-of-two-walk distances vs that for the first walk distance (r = 0.58 vs r = 0.67, respectively, P = .04).

Divay Chandra, et al. Chest. 2012 December;142(6):1545-1552.
2.
Figure 1.

Figure 1. From: Optimizing the 6-Min Walk Test as a Measure of Exercise Capacity in COPD.

Layout of the National Emphysema Treatment Trial showing timing of measurements, sample sizes for the current analysis, and differences that were calculated using data from different time points. Beyond the 6-mo follow-up visit, there were too few patients with two walks per 6-min walk test for a meaningful analysis. LVRS = lung volume reduction surgery; OMT = optimal medical therapy; REHAB = rehabilitation.

Divay Chandra, et al. Chest. 2012 December;142(6):1545-1552.
3.
Figure 3.

Figure 3. From: Optimizing the 6-Min Walk Test as a Measure of Exercise Capacity in COPD.

Power curves for a parallel-arm clinical trial designed to identify an improvement in walk distance of 131.2 ft (40 m) with a two-tailed α of .05. The solid curve uses an SD of 180.2 ft that was observed using the first walk distance during rehabilitation in the National Emphysema Treatment Trial. The dashed and dotted curves represent the left shift in the power curve due to a 14% and 33% reduction in variance, respectively, with a resulting reduction in sample size if patients in the trial performed two instead of one walk for the 6-min walk test and either change in average-of-two or in best-of-two walk distance was used as the final test result.

Divay Chandra, et al. Chest. 2012 December;142(6):1545-1552.

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