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Results: 4

1.
FIG. 2.

FIG. 2. From: Immunization with Culex tarsalis Mosquito Salivary Gland Extract Modulates West Nile Virus Infection and Disease in Mice.

Immunoblot analysis of pooled serum from mice immunized with Cx. tarsalis salivary gland homogenates. Lane 1, molecular mass markers, Lane 2, pooled serum from vaccinated mice, and Lane 3, pooled serum from mock-vaccinated mice. Approximate molecular masses of mosquito salivary proteins recognized by mouse antibodies are indicated by arrows at right.

Carlos Machain-Williams, et al. Viral Immunol. 2013 February;26(1):84-92.
2.
FIG. 3.

FIG. 3. From: Immunization with Culex tarsalis Mosquito Salivary Gland Extract Modulates West Nile Virus Infection and Disease in Mice.

WNV neutralizing antibody titers (PRNT80) in vaccinated and mock-vaccinated mice at days 4 and 8 post WNV challenge. Sera from vaccinated and mock-vaccinated mice were assayed for WNV neutralizing antibodies by 80% plaque-reduction neutralization test (PRNT). Error bars represent the standard error of the mean of two independent experiments, N=8 mice per group. *indicates a significant difference between groups (p<0.0008).

Carlos Machain-Williams, et al. Viral Immunol. 2013 February;26(1):84-92.
3.
FIG. 1.

FIG. 1. From: Immunization with Culex tarsalis Mosquito Salivary Gland Extract Modulates West Nile Virus Infection and Disease in Mice.

Survival of mice immunized with Cx. tarsalis salivary gland homogenates or mock-immunized following WNV challenge by bites of infected Cx. tarsalis. Groups of 8 mice were either vaccinated with mosquito salivary gland extract or mock-immunized and challenged by bites of 3–5 WNV-infected Cx. tarsalis mosquitoes. Mice were euthanized immediately when they exhibited severe neurologic signs of disease. Data from two independent replicates were analyzed; survival was significantly higher in immunized mice (Fisher's exact test; p=0.03).

Carlos Machain-Williams, et al. Viral Immunol. 2013 February;26(1):84-92.
4.
FIG. 4.

FIG. 4. From: Immunization with Culex tarsalis Mosquito Salivary Gland Extract Modulates West Nile Virus Infection and Disease in Mice.

Splenic cytokine mRNA production in vaccinated and mock-vaccinated mice determined by RT-qPCR at days 4 and 8 post-WNV challenge; The Y-axis depicts the ratio of amplified cytokine cDNA to the β-actin gene of each sample. A, IFNγ; B, TNFα; C, IL-4; and D, IL-10. The bars indicate the standard error of the mean and the data are representative of 2 independent experiments, N=8 mice per group and time point. * indicates a significant difference (p<0.05) between groups.

Carlos Machain-Williams, et al. Viral Immunol. 2013 February;26(1):84-92.

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