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1.
Figure 2

Figure 2. From: Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model.

Chondrogenic and osteogenic differentiation of rabbit adipose stem cells (ASCs) in vitro. (A) Chondrogenic and osteogenic differentiation of rabbit ASCs labeled with CM-Dil in vitro. (B) Growth curves of unlabeled and labeled ASCs (C).

Giovanna Desando, et al. Arthritis Res Ther. 2013;15(1):R22-R22.
2.
Figure 4

Figure 4. From: Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model.

Quantitative assessment of disease progression in the different groups. (A) Fibrillation index. (B) Cartilage thickness. Data are reported in terms of mean ± SD. Statistical values of at least P < 0.01 were observed in all the comparisons.

Giovanna Desando, et al. Arthritis Res Ther. 2013;15(1):R22-R22.
3.
Figure 10

Figure 10. From: Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model.

Immunohistochemical analysis for MMP-1 and TNF-α in synovial membrane. Photomicrographs of representative specimens evaluated for MMP-1 (A) and TNF-α (B) in synovial membrane of OA, 4% RSA and ASC-treated groups. Data are reported as mean ± SD. Scale bars = 100 μm. Statistical values of at least P < 0.01 were observed in all the comparisons.

Giovanna Desando, et al. Arthritis Res Ther. 2013;15(1):R22-R22.
4.
Figure 11

Figure 11. From: Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model.

Immunohistochemical analysis for MMP-1 and TNF-α in menisci. Photomicrographs of representative specimens evaluated for MMP-1 (A) and TNF-α (B) in medial menisci of OA, 4% RSA and ASC-treated groups. Data are reported as mean ± SD. Scale bars = 100 μm. Statistical values of at least P < 0.01 were observed in all the comparisons.

Giovanna Desando, et al. Arthritis Res Ther. 2013;15(1):R22-R22.
5.
Figure 9

Figure 9. From: Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model.

Immunohistochemical analysis for MMP-1 and TNF-α in cartilage. Photomicrographs of representative specimens evaluated for MMP-1 (A) and TNF-α (B) in medial femoral condyle of OA, 4% RSA and ASC-treated groups. Data are reported as mean ± SD. Scale bars = 100 μm. Statistical values of at least P < 0.01 were observed in all the comparisons.

Giovanna Desando, et al. Arthritis Res Ther. 2013;15(1):R22-R22.
6.
Figure 6

Figure 6. From: Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model.

Histological evaluation of synovial membrane in OA, 4% RSA and ASC-treated groups. (A) H/E staining of representative specimens. Scale bars = 100 μm. (B) Laverty's score. Data are reported in terms of the 95% confidence intervals. Statistical values of at least P < 0.01 were observed in all the comparisons.

Giovanna Desando, et al. Arthritis Res Ther. 2013;15(1):R22-R22.
7.
Figure 3

Figure 3. From: Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model.

Biodistribution of CM-Dil labeled ASCs. Detection of labeled-ASCs in synovial lining layer (A-D) and medial meniscus (E-H) of representative specimens at 3 and 20 days from ASC administration under bright field (A, C, E, G) and epi-fluorescence (B, D, F, H). Blue staining = nuclei; Red staining = CM-Dil labeled-ASCs. Scale bars = 500 μm.

Giovanna Desando, et al. Arthritis Res Ther. 2013;15(1):R22-R22.
8.
Figure 7

Figure 7. From: Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model.

Histological evaluation of menisci in OA, 4% RSA and ASC-treated groups. (A) Safranin-O/Fast Green staining of representative specimens. Scale bars = 100 μm. (B) Numbers of cluster formation. All the data are reported as 95% confidence intervals. Statistical values of at least P < 0.01 were observed in all the comparisons.

Giovanna Desando, et al. Arthritis Res Ther. 2013;15(1):R22-R22.
9.
Figure 8

Figure 8. From: Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model.

Immunohistochemical analysis for collagen II and I in cartilage. Photomicrographs of representative specimens evaluated for type II (A) and I (B) collagens in medial femoral condyle of OA, 4% RSA and ASC-treated groups. Data are reported as mean ± SD. Scale bars = 100 μm. Statistical values of at least P < 0.01 were observed in all the comparisons.

Giovanna Desando, et al. Arthritis Res Ther. 2013;15(1):R22-R22.
10.
Figure 5

Figure 5. From: Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model.

Histological evaluation of medial femoral condyle in OA, 4% RSA and ASC-treated groups. (A) Safranin-O/Fast Green staining of representative specimens. Black arrows, fibrillation and delamination processes. Red arrows, Erosion processes. Scale bars = 1,000 μm. (B) Laverty's score. Data are reported in terms of 95% confidence intervals. Statistical values of at least P < 0.01 were observed in all the comparisons.

Giovanna Desando, et al. Arthritis Res Ther. 2013;15(1):R22-R22.
11.
Figure 1

Figure 1. From: Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model.

Degenerative changes in different articular compartments in sham and OA groups at eight weeks. (A, B) India ink staining of medial femoral condyle (MFC) of representative specimens. Arrows, fibrillation processes (C, D) Safranin-O/Fast Green staining of cartilage tissue of representative specimens. Arrows: Fibrillation and delamination processes. (E, F) Hematoxylin/Eosin staining of synovial membrane of representative specimens. Black arrows, Thickening of lining layer; Red arrows, Inflammatory cells. (G, H) Safranin-O/Fast Green staining of medial meniscus of representative specimens. Scale bars in C, D = 1 mm; E-H = 100 μm.

Giovanna Desando, et al. Arthritis Res Ther. 2013;15(1):R22-R22.

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