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1.
Figure 3

Figure 3. Hepatic granuloma size and fibrosis is reduced in nude mice versus BALB/c mice, but the same as scid mice.. From: Development of Adult Worms and Granulomatous Pathology Are Collectively Regulated by T- and B-Cells in Mice Infected with Schistosoma japonicum.

(A) granuloma sizes calculated from isolated granulomas at 43 days after infection calculated from three separate granulomas per individual animal. (B) a typical well-formed and multi-cellular granuloma with minimal hepatocyte necrosis (×200) includes a large number of eosinophils in BALB/c. granuloma with a much reduced cellular infiltration and obvious hepatocyte necrosis surrounding egg show the relative selective depletion of eosinophils and cellularity in nude and scid, but there is no difference significant between the two.

Hongbin Tang, et al. PLoS One. 2013; 2013;8(1):e54432.
2.
Figure 1

Figure 1. The effects of CD4+ T cell deficiency on the development of worms.. From: Development of Adult Worms and Granulomatous Pathology Are Collectively Regulated by T- and B-Cells in Mice Infected with Schistosoma japonicum.

(A) Flow cytometric analysis of peripheral blood CD4+ lymphocytes in scid, nude and BALB/c mice, recovered at 43 days p.i. Presented are % of cells detected in CD3 gate as a mean from one of 2 experiments with 4 mice per group. (B) Parasites were recovered from the portal tract at 29, 36, 43 days p.i., and male and female worm sizes were determined based on digital micrographs. Mean values are represented by horizontal bars. (C) Total number of worms and worm pairs in nude and BALB/c mice at 29, 36, 43 days p.i… Data are represented as median± SEM.

Hongbin Tang, et al. PLoS One. 2013; 2013;8(1):e54432.
3.
Figure 2

Figure 2. B cells and T cells play crucial roles for development and reproduction of schistosomes.. From: Development of Adult Worms and Granulomatous Pathology Are Collectively Regulated by T- and B-Cells in Mice Infected with Schistosoma japonicum.

(A) Flow cytometric analysis of peripheral blood B lymphocytes in scid, nude and BALB/c mice; peripheral blood was recovered at 43 days p.i… Presented are, % of cells in the CD45R gate as mean from one of two experiments), with 4 mice per group. (B) Sizes of parasites from scid and nude mice were measured from digital micrographs. (C) Total number of worms and worm pairs recovered from scid, nude, or BALB/c mice were compared at 29, 36, 43 days p.i… Data are represented as median± SEM. (D) Egg production by schistosome pairs, as in C. (E) IL-10 cytokine secretions, measured by ELISA, in scid (white bars), nude (gray bar) and BALB/c (black bar) mice at 29, 36, 43 days p.i. (F) Representative micrographs of parasites recovered from BALB/c mice, nude mice, or scid mice at the time points indicated p.i. (10× magnification).

Hongbin Tang, et al. PLoS One. 2013; 2013;8(1):e54432.

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