Results: 3

1.
Figure 3

Figure 3. Hk2 and Nck2 Immunohistochemistory.. From: Association of HK2 and NCK2 with Normal Tension Glaucoma in the Japanese Population.

Representative IHC photographs showing Hk2, Nck2, astrocyte maker (GFAP) and RGC marker (C38) in the retinas of untreated mice. Arrows indicated the co-localization area.

Dong Shi, et al. PLoS One. 2013;8(1):e54115.
2.
Figure 2

Figure 2. High-density scan of the GLC1B region on chromosome 2 to identify candidate glaucoma genes.. From: Association of HK2 and NCK2 with Normal Tension Glaucoma in the Japanese Population.

Six SNPs that showed significant evidence of association with POAG or NTG (p<0.01) and the previously-reported candidate NCK2 gene are shown. Vertical line shows p value (−log10), and horizontal line shows chromosomal location (kb).

Dong Shi, et al. PLoS One. 2013;8(1):e54115.
3.
Figure 1

Figure 1. Experimental Study Design.. From: Association of HK2 and NCK2 with Normal Tension Glaucoma in the Japanese Population.

The study used a first stage of SNP screening in one population to identify SNPs and genes to be tested in a second population through SNP association testing and mutation screening of genes containing SNPs associated with glaucoma. Stage Two tested SNPs for association in a second population and did mutation screening in that second population in genes containing SNPs that showed significant association with POAG or NTG (p<0.01) in Stage One of our study or that had been previously reported to show significant evidence of association [16].

Dong Shi, et al. PLoS One. 2013;8(1):e54115.

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