Results: 2

1.
Figure 1

Figure 1. Relationships of PPARG co-activator 1 alpha (PPARGC1A) with AMD-associated genes or their products.. From: DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ?-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways.

Genes associated with AMD in extant studies are shaded in red. DHA = docosahexaenoic acid (a PPAR agonist). Diagram was generated with Ingenuity Pathway Analysis® software. Full names for genes represented by symbols exist at http://www.ncbi.nlm.nih.gov/gene/. Direct effects of PPARGC1A are represented by blue arrows. Letters on the arrows represent the nature of evidence and are defined as follows: A = activation, E = expression, L = proteolysis, PP = protein-protein interaction, T = transcription.

John Paul SanGiovanni, et al. PLoS One. 2013;8(1):e53155.
2.
Figure 2

Figure 2. Dietary treatment of ω-3 PUFA protects against pathologic retinal neovascularization.. From: DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ?-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways.

C57 BL/6 mouse pups fed with ω-3 or ω-6 PUFA enhanced diet were exposed to oxygen-induced retinopathy. Retinas were flat mounted at postnatal day (P) 17 to visualize vasculature with contralateral retinas from the same mice isolated for gene array analysis. (a). Representative retina vasculature stained with isolectin B4 shows vaso-obliteration and pathologic neovascularization in ω-6 or ω-3 fed mice. (ω-6, n = 7 and ω-3, n = 8). Scale bar: 1mm. Quantification of (b) vaso-obliteration and (c) neovascularization in ω-6 or ω-3 fed mice. * P≤0.05, *** P≤0.001.

John Paul SanGiovanni, et al. PLoS One. 2013;8(1):e53155.

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