Results: 2

1.
Figure 2

Figure 2. From: Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.

Leptin receptor activity measured by STAT3 mediated luciferase response. HEK293 cells (n = 8 separate experiments) were co-transfected with LEPRb, a STAT3 responsive element and SH2B1 splice variants beta (left) and gamma (right) with and without the infrequent alleles at rs7498665 (Thr484Ala) and βThr656Ile/γPro674Ser. The dose response curves depict leptin receptor activity after stimulation with leptin (exact values for each data point see Additional file 1: Table S2).

Anna-Lena Volckmar, et al. BMC Med Genomics. 2012;5:65-65.
2.
Figure 1

Figure 1. From: Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.

Flow chart for experimental setup. GWAS: genome-wide association study; SNP: single nucleotide polymorphism; dHPLC: denaturating high performance liquid chromatography; DAPOC: Datteln Paediatric Obese Cohort (Reinehr et al. 2007); KORA: Cooperative Health Research in the Region of Augsburg (Wichmann et al. 2005); Ulm children’s study 1: Ulm Research on Metabolism, Exercise and Lifestyle in Children (Nagel et al. 2009); BEPOC: Berlin Paediatric Obese Cohort (Bau et al. 2009); Ulm children’s study 2 and 3: Ulm Paediatric Obese Cohort A and B (INSULA) (Wabitsch et al. 2004).

Anna-Lena Volckmar, et al. BMC Med Genomics. 2012;5:65-65.

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