We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 5

1.
Fig. 5

Fig. 5. From: Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures.

Aschematic illustration of the interaction of NMDARs with PSD-95 and CaMKII.

Yeon Joo Jung, et al. Korean J Physiol Pharmacol. 2012 December;16(6):423-429.
2.
Fig. 4

Fig. 4. From: Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures.

Representative western blots for PSD-95, NR, NR2B, and CaMKII after OGD/reperfusion. (A) At 24 h after OGD, the levels of all the PSD complex proteins were decreased. (B) Data are expressed as mean±SEM. *p<0.05 vs. the control. n=3.

Yeon Joo Jung, et al. Korean J Physiol Pharmacol. 2012 December;16(6):423-429.
3.
Fig. 1

Fig. 1. From: Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures.

Light micrographs of the CA3 pyramidal cell layer of organotypic hippocampal slice cultures, stained with toluidine blue, after OGD/reperfusion. (A) Control, (B) OGD for 30 min, (C) reperfusion for 6 h after OGD, (D) reperfusion for 24 h after OGD. Neuronal cell death was induced after OGD/reperfusion. Black arrows indicate condensed pyknotic nuclei, and white arrows indicate cells stained dark, with triangular shrunken perikaryon. Scale bar=100 µm.

Yeon Joo Jung, et al. Korean J Physiol Pharmacol. 2012 December;16(6):423-429.
4.
Fig. 2

Fig. 2. From: Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures.

Electron micrographs of osmiumuranium-lead-stained stratum lucidum in the CA3 area of organotypic hippocampal slice cultures after OGD/reperfusion. (A, E) control, (B, F) OGD for 30 min, (C, G) reperfusion for 6 h after OGD, (D, H) reperfusion for 24 h after OGD. (E~H) higher magnification images. In control slices, typical intact synapses with a clear narrow synaptic cleft can be clearly seen (arrowhead). Mitochondria, ER, dendrites, and synaptic terminals were swollen, and the thickness of the PSD in many synapses became thicker (black arrows) in the OGD/reperfusion group than in the controls. Scale bar=2 µm.

Yeon Joo Jung, et al. Korean J Physiol Pharmacol. 2012 December;16(6):423-429.
5.
Fig. 3

Fig. 3. From: Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures.

Electron micrographs of EPTA staining of stratum lucidum in the CA3 area of organotypic hippocampal slice cultures after OGD/reperfusion. (A) Control, (B) reperfusion for 24 h after OGD. (C) Synapse density/100 µm2, (D) length of a PSD, (E) minimum and maximum thickness of a PSD, (F) area of a PSD. In the control slices, many PSDs appeared as thin and compact lines. At 24 h after OGD, the density of PSDs was significantly decreased, and the PSDs became thicker, longer, and more irregular. Insert images are high magnification of the synapses. Scale bar=1 µm. Data are expressed as mean±SEM. *p<0.05 compared to control.

Yeon Joo Jung, et al. Korean J Physiol Pharmacol. 2012 December;16(6):423-429.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk