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1.
Figure 2

Figure 2. Relative fraction of time spent in the severe disease under six different scenarios.. From: When Does Overuse of Antibiotics Become a Tragedy of the Commons?.

The -axes are the community level of treatment, i.e. the strategy assumed chosen by all other members of the community. The -axes are the level of treatment chosen by an individual within the community. The contour plot shows the fraction of time spent by this person, in the severe state; each panel has been scaled so that the minimum value is zero (blue) and the maximum value is 1 (red). The numerical parameter choices are given in Table 2, and the minimum and maximum values for each panel.

Travis C. Porco, et al. PLoS One. 2012;7(12):e46505.
2.
Figure 1

Figure 1. Compartmental flow diagram for Model 2.. From: When Does Overuse of Antibiotics Become a Tragedy of the Commons?.

Each circle represents a state variable; each arrow a transition. The state variables are: —the number of uninfected individuals, —the number of individuals with mild infection by the drug-sensitive organism, —the number of individuals with severe infection by the drug-sensitive organism, —the number of individuals with mild infection by the drug-resistant organism, and —the number of individuals with severe infection by the drug-resistant organism. Treatment rates for the mild and severe state are given by and , respectively. The arrows are labeled with per-individual flow rates; the total flow rate from each state along each arrow is given by the label of the arrow times the number of individuals in the state. The explicit differential equations and parameter definitions are given in the main text.

Travis C. Porco, et al. PLoS One. 2012;7(12):e46505.
3.
Figure 3

Figure 3. Assessment of the effect of over-treatment of mild infection on the treatment of mild infections.. From: When Does Overuse of Antibiotics Become a Tragedy of the Commons?.

It was assumed that severely infected individuals do not transmit, and that drug resistance does not develop during treatment of severe infections. The mean time to treatment is set at 5 (arbitrary units) for mild infection, and 1/3 units for severe infection. All other expected waiting times (recovery, progression) are equal to 1. The reproduction number for the drug-sensitive organism is 1.5. See Text for full details of Model 2. Under these assumptions, the drug-resistant organism competitively excludes the drug-sensitive organism whenever the relative transmissibility exceeds 10/11 (91%) (grey area, labeled “No sensitive strain”). The parameters are , , , , , , and . The horizontal axis corresponds to and the vertical axis to .

Travis C. Porco, et al. PLoS One. 2012;7(12):e46505.

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