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Results: 5

1.
Figure 3

Figure 3. Group differences in network volume.. From: scMRI Reveals Large-Scale Brain Network Abnormalities in Autism.

Plots of voxel counts by group indicate substantially restricted network extent in the SN of autistic subjects, whereas the DMN is more spatially extensive in the autistic group. Y-axis scale is voxel number from associated statistical maps. AUT, autism group; CTRL, control group; DMN, default mode network; L, left; R, right; SN, salience network.

Brandon A. Zielinski, et al. PLoS One. 2012;7(11):e49172.
2.
Figure 1

Figure 1. Structural covariance maps of the salience network in autism and controls.. From: scMRI Reveals Large-Scale Brain Network Abnormalities in Autism.

Statistical parametric maps depict brain regions in which gray matter intensity covaried with that of the seed ROI (right FI) in each group. (A) Structural covariance patterns appear substantially spatially restricted in autism (hot colors; see also Table 2). (B) Corresponding scMRI map in normal controls corresponds to a robust canonical SN (cool colors). (C) scMRI maps from both groups overlaid on a single anatomic volume. scMRI data are T-statistic maps (p<0.01, FWE-corrected) displayed on the average anatomical template of all subjects. The left side of the image corresponds to the right side of the brain. FI, frontoinsula; FWE, family-wise error; ROI, region of interest; scMRI, structural covariance MRI; SN, salience network.

Brandon A. Zielinski, et al. PLoS One. 2012;7(11):e49172.
3.
Figure 5

Figure 5. Whole brain structural covariance with ADOS-SI scores as a result of direct between-group contrasts.. From: scMRI Reveals Large-Scale Brain Network Abnormalities in Autism.

Statistical parametric maps depict brain regions in which gray matter intensity covaried with ADOS Social Impairment (ADOS-SI) score differently between groups. In controls, ADOS-SI scores covaried with frontal regions overlapping with SN including medial frontal wall, anterior cingulate, and frontoinsular cortex. In contrast, in autistic subjects ADOS-SI covaried with posterior brain regions including cuneus, precuneus, parieto-occipital regions, and temporoparietal cortex. scMRI data are T-statistic maps (p<0.05, inclusively masked to the network global map for both groups at p<0.01 FWE) displayed on the average anatomical template of all subjects. scMRI maps from both groups overlaid on a single anatomic volume reveal distinct between-group differences. The left side of the image corresponds to the right side of the brain. SN, salience network.

Brandon A. Zielinski, et al. PLoS One. 2012;7(11):e49172.
4.
Figure 2

Figure 2. Structural covariance maps of the default mode network in autism and controls.. From: scMRI Reveals Large-Scale Brain Network Abnormalities in Autism.

Statistical parametric maps depict brain regions in which gray matter intensity covaried with that of the seed ROI (right PCC) in each group. (A) Structural covariance patterns appear robust in posterior brain regions, but restricted in frontal areas in autism (hot colors; see also Table 2). Covariance outside of canonical DMN boundaries is also evidenced. (B) Corresponding scMRI map in normal controls corresponds to a robust canonical default mode network (cool colors). (C) scMRI maps from both groups overlaid on a single anatomic volume. scMRI data are T-statistic maps (p<0.01, FWE-corrected) displayed on the average anatomical template of all subjects. The left side of the image corresponds to the right side of the brain. DMN, default mode network; FWE, family-wise error; PCC, posterior cingulate cortex; ROI, region of interest; scMRI, structural covariance MRI.

Brandon A. Zielinski, et al. PLoS One. 2012;7(11):e49172.
5.
Figure 4

Figure 4. Structural covariance maps of salience and default mode networks as a result of direct between-group contrasts.. From: scMRI Reveals Large-Scale Brain Network Abnormalities in Autism.

Statistical parametric maps depict brain regions in which gray matter intensity covaried with that of the seed ROI (right FI or PCC) differently between groups. (A) Structural covariance with right FI is greater in bilateral SMA in autistic subjects (hot colors; see also Table 3), whereas control subjects (cool colors) demonstrate more robust covariance in extensive frontal and temporal brain regions, in addition to insular cortex. Covariance outside of canonical SN boundaries is evidenced only in the autistic group. (B) Structural covariance with right PCC includes posterior cingulate, parieto-occipital, and temporal brain regions in autism (hot colors), whereas frontal covariance is absent. In contrast, control subjects demonstrate more robust covariance in frontal, lateral inferior parietal, and paracentral regions (cool colors; see also Table 3). Covariance outside of canonical DMN boundaries is evidenced only in the autistic group. scMRI data are T-statistic maps (p<0.05, inclusively masked to the network global map for both groups at p<0.01 FWE) displayed on the average anatomical template of all subjects. The left side of the image corresponds to the right side of the brain. DMN, default mode network; FI, frontoinsula; FWE, family-wise error; PCC, posterior cingulate cortex; ROI, region of interest; SN, salience network.

Brandon A. Zielinski, et al. PLoS One. 2012;7(11):e49172.

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