Results: 2

1.
Figure 1

Figure 1. From: Anthrax Lethal Toxin and the Induction of CD4 T Cell Immunity.

A schematic ribbon diagram depicting the Lethal Factor protein. Within the domain IV catalytic center we have identified a number of T cell epitopes, represented in white [49]. LF is capable of inactivating key cellular pathways, as the majority of these functions are related to the active center, epitopes within this region may prove crucial in the development of a vaccine capable of successfully inhibiting the toxin. This figure was generated using the Accelrys discovery studio client 2.5 program.

Stephanie Ascough, et al. Toxins (Basel). 2012 October;4(10):878-899.
2.
Figure 2

Figure 2. From: Anthrax Lethal Toxin and the Induction of CD4 T Cell Immunity.

Model of cellular intoxication by LT. The 83 kDa PA protein secreted by B. anthracis binds to the host cell surface receptor (ANTXR1/TEM8, ANTXR2/CMG2 or the integrins α4β1 and α5β1), and is proteolytically cleaved by host furin, releasing a 20 kDa fragment from the N-terminal of the protein. The remaining 63 kDa PA fragment heptamerises and binds to LF to form LT. The toxins are then internalised in endosomal vesicles which are subsequently acidified, triggering the translocation of LT into the host cytosol. LT inactivates the MKKs, the central step in the MAPK signaling pathway, and induces the Nlrp1 activation of the inflammasome.

Stephanie Ascough, et al. Toxins (Basel). 2012 October;4(10):878-899.

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